N-Boc-DL-3-FluoroPhenylglycine

Base Information

• Chemical Name: N-Boc-DL-3-FluoroPhenylglycine
• CAS No.: 142121-94-6
• Molecular Formula: C13H16FNO4
• Molecular Weight: 269.273
• Hs Code.: 2922509090
• Mol file: 142121-94-6.mol

Synonyms:N-Boc-DL-3-FluoroPhenylglycine

Chemical Property of N-Boc-DL-3-FluoroPhenylglycine

Chemical Property:

• PSA: 66.84000
• LogP: 2.65180
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-((tert-Butoxycarbonyl)(3-fluorophenyl)amino)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-DL-3-FluoroPhenylglycine

There total 8 articles about N-Boc-DL-3-FluoroPhenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

di-tert-butyl dicarbonate (24424-99-5) + DL-2-(3-fluorophenyl)glycine (7292-74-2) → 2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetic acid (142121-94-6,1228542-64-0)

Guidance literature:

di-tert-butyl dicarbonate; DL-2-(3-fluorophenyl)glycine; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 15h;

With hydrogenchloride; In water; pH=1; Cooling;

Reference yield:

3-fluorophenylacetonitrile (501-00-8) → 2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetic acid (142121-94-6,1228542-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: isobutyl nitrite, aq. KOH / methanol / 26 h / 50 - 90 °C

2: H₂, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

3: 2N aq. NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; nitrous acid isobutyl ester; hydrogen; palladium on activated charcoal; In methanol; ethanol; tert-butyl alcohol;

DOI:10.1021/jm00055a002

Reference yield:

(3-Fluoro-phenyl)-[(E)-hydroxyimino]-acetic acid → 2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetic acid (142121-94-6,1228542-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

2: 2N aq. NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; tert-butyl alcohol;

DOI:10.1021/jm00055a002

upstream raw materials:

carbon dioxide

N-(tert-butyloxycarbonyl)-3-fluorobenzylamine

di-tert-butyl dicarbonate

DL-2-(3-fluorophenyl)glycine

Downstream raw materials:

(3R)-3-(2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide

(R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetate