4-(2-Chlorophenyl)pyrrolidin-2-one

Base Information

Chemical Name:4-(2-Chlorophenyl)pyrrolidin-2-one
CAS No.:28311-22-0
Molecular Formula:C10H10ClNO
Molecular Weight:195.648
Hs Code.:2933790090
DSSTox Substance ID:DTXSID80402149
Mol file:28311-22-0.mol

Synonyms:4-(2-chlorophenyl)pyrrolidin-2-one;28311-22-0;(4R)-4-(2-chlorophenyl)pyrrolidin-2-one;2-Pyrolidinone, 4-(2-Chlorophenyl);SCHEMBL10759562;DTXSID80402149;AKOS006279200;AS-76667;CS-0054183;EU-0077186;EN300-1669797;A853567;SR-01000483347;SR-01000483347-1

Suppliers and Price of 4-(2-Chlorophenyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(2-Chlorophenyl)pyrrolidin-2-one 95+%
1g
$ 460.00

Chemenu
4-(2-Chlorophenyl)pyrrolidin-2-one 95%
1g
$ 430.00

American Custom Chemicals Corporation
4-(2-CHLOROPHENYL)PYRROLIDIN-2-ONE 95.00%
5MG
$ 499.03

Alichem
4-(2-Chlorophenyl)pyrrolidin-2-one
1g
$ 862.16

Alichem
4-(2-Chlorophenyl)pyrrolidin-2-one
250mg
$ 348.60

Total 14 raw suppliers

Chemical Property of 4-(2-Chlorophenyl)pyrrolidin-2-one

Chemical Property:

PSA：32.59000
LogP:2.21940
Storage Temp.:2-8°C
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:195.0450916
Heavy Atom Count:13
Complexity:207

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Chlorophenyl)pyrrolidin-2-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CNC1=O)C2=CC=CC=C2Cl

Technology Process of 4-(2-Chlorophenyl)pyrrolidin-2-one

There total 6 articles about 4-(2-Chlorophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2-oxo-4-(2-chlorophenyl)pyrrolidine-3-carboxylic acid

: 28311-22-0
4-(2-chlorophenyl)pyrrolidin-2-one

Guidance literature:: In toluene; for 5h; Reflux;
DOI:10.3390/molecules201219830

Reference yield:

: 1062307-62-3
diethyl 2-(1-(2-chlorophenyl)-2-nitroethyl)malonate

: 28311-22-0
4-(2-chlorophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / methanol / 2.5 h / 20 °C / 3102.97 Torr

2: sodium hydroxide / ethanol / 48 h / 20 °C

3: toluene / 5 h / Reflux

With hydrogen; sodium hydroxide; In methanol; ethanol; toluene;
DOI:10.3390/molecules201219830

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 28311-22-0
4-(2-chlorophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / toluene / 48 h / Reflux

2: potassium carbonate / toluene / 48 h / 20 °C

3: hydrogen / methanol / 2.5 h / 20 °C / 3102.97 Torr

4: sodium hydroxide / ethanol / 48 h / 20 °C

5: toluene / 5 h / Reflux

With piperidine; hydrogen; potassium carbonate; sodium hydroxide; In methanol; ethanol; toluene; 1: |Knoevenagel Condensation / 2: |Michael Addition;
DOI:10.3390/molecules201219830