3-(Bromomethyl)-2-methylpyridine

Base Information

• Chemical Name: 3-(Bromomethyl)-2-methylpyridine
• CAS No.: 76915-53-2
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.05
• Hs Code.: 2933399090
• European Community (EC) Number: 807-511-5
• DSSTox Substance ID: DTXSID60507020
• Wikidata: Q72447393
• Mol file: 76915-53-2.mol

Synonyms:3-(BROMOMETHYL)-2-METHYLPYRIDINE;76915-53-2;PYRIDINE, 3-(BROMOMETHYL)-2-METHYL-;SCHEMBL5802969;DTXSID60507020;MFCD11847412;AKOS016008955;PB19196;SY348140;CS-0057684;EN300-623967;P11218;J-510822

Chemical Property of 3-(Bromomethyl)-2-methylpyridine

Chemical Property:

• Boiling Point: 233℃
• Flash Point: 95℃
• PSA: 12.89000
• Density: 1.448
• LogP: 2.28490
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 184.98401
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

97% ^*data from raw suppliers

3-(Bromomethyl)-2-methylpyridine hydrobromide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC=N1)CBr

Technology Process of 3-(Bromomethyl)-2-methylpyridine

There total 4 articles about 3-(Bromomethyl)-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-methylpyridin-3-yl)methanol (56826-61-0) → 3-(bromomethyl)-2-methylpyridine (76915-53-2)

Guidance literature:

With phosphorus tribromide; In diethyl ether; for 1h;

DOI:10.1021/jo00323a016

Reference yield:

2,3-Lutidine (583-61-9) → 3-(bromomethyl)-2-methylpyridine (76915-53-2)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 1.5h; Heating; Irradiation;

DOI:10.1021/jo00323a016

Reference yield:

ethyl 2-methyl nicotinate (1721-26-2) → 3-(bromomethyl)-2-methylpyridine (76915-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 1 h / Ambient temperature

2: PBr₃ / diethyl ether / 1 h

With lithium aluminium tetrahydride; phosphorus tribromide; In diethyl ether;

DOI:10.1021/jo00323a016

upstream raw materials:

2,3-Lutidine

(2-methylpyridin-3-yl)methanol

ethyl 2-methyl nicotinate

2-methylnicotinic acid

Downstream raw materials:

(2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-pyridin-3-ylmethoxy)-benzenesulfonyl]-piperidine-2-carboxylic acid tert-butyl ester

3-Benzenesulfinylmethyl-2-methyl-pyridine

7,8-dihydroquinolin-6(5H)-one

2-(Bromomethyl)-3-<(phenylsulfonyl)methyl>pyridine