56826-61-0

Usage

InChI:InChI=1/C5H4O2/c6-4-5-2-1-3-7-5/h1-4H

Upstream product

• 1721-26-2 ethyl 2-methyl nicotinate 
• 65719-09-7 methyl 2-methylnicotinate 
• 144-55-8 sodium hydrogencarbonate 
• 60032-57-7 2-methylnicotinaldehyde 
• 64987-16-2 (2-amino-thiazol-4-yl)-acetic acid methyl ester 
• 3222-56-8 2-methylnicotinic acid 
• 90643-19-9 2-methyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 

Downstream Products

• 98593-18-1 3-methoxymethyl-2-methyl-pyridine 
• 100710-48-3 3-benzyloximethyl-2-methyl-pyridine 
• 76915-53-2 3-(bromomethyl)-2-methylpyridine 
• 58539-77-8 2-methyl-3-chloromethylpyridine hydrochloride 
• 120277-68-1 2-methyl-3-(chloromethyl)pyridine 
• 73843-36-4 3-Benzenesulfonylmethyl-2-methyl-pyridine 
• 76915-54-3 2-Methyl-3-<(phenylthio)methyl>pyridine 
• 76915-76-9 2-<(Phenylthio)methyl>-3-(3-oxo-1(E)-buten-1-yl)pyridine 
• 345207-79-6 2-Methyl-3-<1-(phenylthio)-2-hydroxy-2-methylbut-1-yl>pyridine 
• 76915-77-0 2-<(Phenylsulfonyl)methyl>-3-(3-oxo-1(E)-propen-1-yl)pyridine 
• 345207-78-5 2-Methyl-3-<1-(phenylthio)-2-hydroxy-3-methylbut-1-yl>pyridine 
• 76915-79-2 3-(2-Benzenesulfonylmethyl-pyridin-3-yl)-propan-1-ol 
• 76915-75-8 3-(1-Benzenesulfonyl-but-3-enyl)-2-((E)-buta-1,3-dienyl)-pyridine 
• 76915-78-1 2-<(Phenylsulfonyl)methyl>-3-(3-oxoprop-1-yl)pyridine 

Relevant academic research and scientific papers

Novel heterocyclic derivative capable of being used as SHP2 inhibitor

The invention relates to a novel heterocyclic derivative capable of being used as an SHP2 inhibitor, specifically relates to a compound shown by a formula I or pharmaceutically acceptable salts thereof, further relates to a use of the compound shown by the formula I or the pharmaceutically acceptable salts thereof and a pharmaceutical composition thereof in drug preparation, and particularly relates to a use in preparation of drugs for treatment, inhibition or prevention of diseases or discomforts mediated by SHP2 activity.

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Lewis Acid-Catalyzed C(sp3)–C(sp3) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives

An efficient Lewis acid-catalyzed C(sp3)–C(sp3) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro-5H-isoquinolino[2,1-g][1,6]naphthyridine derivatives. A wide range of 2-methylquinoline-3-carbaldehydes and 1,2,3,4-tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields. (Figure presented.).

Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

NEW COMPOUNDS V

The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associate

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)

Alpha-substituted arylalkyl phosphonate derivatives

The present invention relates to novel α-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lo

HIV protease inhibiting compounds

A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Potentiators of glutamate receptors

The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.