Fmoc-Hyp-OBz

Base Information

• Chemical Name: Fmoc-Hyp-OBz
• CAS No.: 439290-35-4
• Molecular Formula: C27H25NO5
• Molecular Weight: 443.49
• Mol file: 439290-35-4.mol

Synonyms:(2S,4S)-1-((9H-Fluoren-9-yl)methyl) 2-benzyl 4-hydroxypyrrolidine-1,2-dicarboxylate;Fmoc-Hyp-Obzl;

Chemical Property of Fmoc-Hyp-OBz

Chemical Property:

• PSA: 76.07000
• Density: 1.315±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 4.05200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-Hyp-Obzl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fmoc-Hyp-OBz

There total 1 articles about Fmoc-Hyp-OBz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.2%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (4S)-4-hydroxy-L-proline benzyl ester p-toluenesulfonyl salt (136124-33-9) → (2S,4S)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-(9H-fluoren-9-ylmethyl) ester (439290-35-4)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 20 ℃;

DOI:10.1021/jo049103g

Reference yield: 88.5%

tert-butyldimethylsilyl chloride (18162-48-6) + (2S,4S)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-(9H-fluoren-9-ylmethyl) ester (439290-35-4) → 4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:

With 1-methyl-1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo049103g

Reference yield: 84.0%

isobutene (115-11-7,15220-85-6) + (2S,4S)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-(9H-fluoren-9-ylmethyl) ester (439290-35-4) → N-(9-fluorenylmethoxycarbonyl)-(2S,4S)-4-tert-butoxyproline benzyl ester (1239474-21-5)

Guidance literature:

With sulfuric acid; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ja103082y

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(4S)-4-hydroxy-L-proline benzyl ester p-toluenesulfonyl salt

Downstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-(2S,4S)-4-tert-butoxyproline benzyl ester