(R)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate
• CAS No.: 1002359-91-2
• Molecular Formula: C11H20BrNO2
• Molecular Weight: 278.186
• Hs Code.: 2933399090
• Mol file: 1002359-91-2.mol

Synonyms:(R)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate

Chemical Property of (R)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate

Chemical Property:

• PSA: 29.54000
• LogP: 2.96630
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl3-(bromomethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate

There total 3 articles about (R)-tert-Butyl 3-(bromomethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (116574-71-1,140645-19-8,140695-84-7,140695-85-8) → tert-butyl (3R)-3-(bromomethyl)piperidine-1-carbamate (1002359-91-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 25 ℃; for 8h;

DOI:10.1021/acs.jmedchem.0c01411

Reference yield:

(R)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester (161285-05-8) → tert-butyl (3R)-3-(bromomethyl)piperidine-1-carbamate (1002359-91-2)

Guidance literature:

With lithium bromide; In acetone; Reflux;

DOI:10.1016/j.ejmech.2017.12.079

Reference yield:

tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate (140695-84-7) → tert-butyl (3R)-3-(bromomethyl)piperidine-1-carbamate (1002359-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: lithium bromide / acetone / Reflux

With triethylamine; lithium bromide; In dichloromethane; acetone;

DOI:10.1016/j.ejmech.2017.12.079

upstream raw materials:

tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate

tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate

(R)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester