6-Chloro-1H-pyrazolo[4,3-c]pyridine

Base Information

• Chemical Name: 6-Chloro-1H-pyrazolo[4,3-c]pyridine
• CAS No.: 1206979-33-0
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.571
• Hs Code.: 2933990090
• Mol file: 1206979-33-0.mol

Synonyms:6-Chloro-1H-pyrazolo[4,3-c]pyridine;1H-Pyrazolo[4,3-c]pyridine, 6-chloro-

Chemical Property of 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Chemical Property:

• Boiling Point: 358℃
• PKA: 10.46±0.40(Predicted)
• Flash Point: 201℃
• PSA: 41.57000
• Density: 1.531
• LogP: 1.61130
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-1H-pyrazolo[4,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-1H-pyrazolo[4,3-c]pyridine

There total 9 articles about 6-Chloro-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.4%

2,4-dichloro-5-pyridinecarboxaldehyde (1060811-62-2) → 6-chloro-1H-pyrazolo[4,3-c]pyridine (1206979-33-0)

Guidance literature:

With hydrazine hydrate; In 1,2-dimethoxyethane; at 75 ℃; for 16h;

Reference yield:

1H-pyrazolo[4,3-c]pyridine N-oxide (871836-50-9) → 4-chloro-1H-pyrazolo [4,3-c]pyridine (871836-51-0) + 6-chloro-1H-pyrazolo[4,3-c]pyridine (1206979-33-0)

Guidance literature:

With trichlorophosphate; for 3h; Heating / reflux;

Reference yield:

2,4-dichloro-5-hydroxymethylpyridine (73998-95-5) → 6-chloro-1H-pyrazolo[4,3-c]pyridine (1206979-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / chloroform / 12 h / 75 °C

2: hydrazine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 80 °C

With manganese(IV) oxide; N-ethyl-N,N-diisopropylamine; hydrazine; In chloroform; N,N-dimethyl acetamide;

upstream raw materials:

1H-pyrazolo[4,3-c]pyridine N-oxide

2,4-dichloro-5-pyridinecarboxaldehyde

2,4-dichloro-5-hydroxymethylpyridine

methyl 4,6-dichloropyridine-3-carboxylate

Downstream raw materials:

C₂₀H₂₁N₇O

1-benzyl-6-chloro-1H-pyrazolo[4,3-c]pyridine

2-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-4-fluorobenzonitrile

4-(3-((6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)-2,5-difluorophenyl)morpholin-3-one

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