73998-95-5

Basic information

• Product Name: 4,6-DICHLORO-3-PYRIDINEMETHANOL
• Synonyms: 4,6-DICHLORO-3-PYRIDINEMETHANOL;4,6-DICHLOROPYRIDINE-3-METHANOL;(4,6-Dichloro-3-pyridinyl)methanol;(4,6-dichloropyridin-3-yl)Methanol;2,4-Dichloro-5-(hydroxymethyl)pyridine;(4,6-Dichloro-3-pyridyl)methanol
• CAS NO: 73998-95-5
• Molecular Formula: C₆H₅Cl₂NO
• Molecular Weight: 178.02
• Mol File: 73998-95-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 298℃
• Flash Point: 134℃
• Appearance: /
• Density: 1.478
• Vapor Pressure: 0.00057mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12?+-.0.10(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-3-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-3-PYRIDINEMETHANOL(73998-95-5)
• EPA Substance Registry System: 4,6-DICHLORO-3-PYRIDINEMETHANOL(73998-95-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 73998-95-5(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-3-pyridinemethanol is a chemical compound with the molecular formula C6H5Cl2NO. It is a white crystalline solid that is used as a building block in the synthesis of pharmaceuticals and agrochemicals. 4,6-DICHLORO-3-PYRIDINEMETHANOL is known for its broad-spectrum fungicidal properties and is commonly used as an antifungal agent in agricultural and industrial applications. It works by inhibiting the growth of fungus and preventing the spread of fungal infections. 4,6-Dichloro-3-pyridinemethanol is also used in the production of veterinary medicines and is an important compound in the field of chemical research.

InChI:InChI=1/C6H5Cl2NO/c7-5-1-6(8)9-2-4(5)3-10/h1-2,10H,3H2

Upstream product

• 1060811-62-2 2,4-dichloro-5-pyridinecarboxaldehyde 
• 73027-79-9 4,6-dichloro-nicotinic acid 
• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 7440-44-0 pyrographite 
• 275383-22-7 2,4-dichloro-5-nitrobenzyl alcohol 
• 65973-52-6 methyl 4,6-dichloropyridine-3-carboxylate 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 

Downstream Products

• 449811-29-4 6-chloro-4-(methylamino)pyridine-3-carbaldehyde 

Relevant articles and documents

Development of a Rapid Scale-Up Synthesis of (S)-N-(8-((2-Amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide, a Potent Adaptor-Associated Kinase 1 Inhibitor

(S)-N-(8-((2-Amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide (1) is a potent adaptor-associated kinase 1 inhibitor, which may have the potential to treat neuropathic pain and other neurological disorders including schizophrenia, Parkinson’s disease, bipolar disorder, and Alzheimer’s disease. For preclinical studies, a substantial amount of high-quality material was required. The original discovery route for the preparation of this compound suffered from scale-up issues that included a very low-yielding C-O coupling step and the use of expensive and toxic reagents. This paper describes a rapid scale-up synthesis accomplished in eight steps, which involves the coupling of phenol 17 with oxathiazolidine 18 as the key transformation.

CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

3,4-dihydropyrido[4,3-d]pyrimidine derivative, and preparation method and use thereof

The invention relates to a 3,4-dihydropyrido[4,3-d]pyrimidine derivative, and a preparation method and a use thereof. The compound is a compound represented by formula I, or a pharmaceutically acceptable salt or stereoisomer or tautomer thereof, and R to R are as defined in the description.