4,6-dichloronicotinoyl chloride

Base Information

• Chemical Name: 4,6-dichloronicotinoyl chloride
• CAS No.: 107836-75-9
• Molecular Formula: C6H2Cl3NO
• Molecular Weight: 210.447
• Hs Code.: 2933399090
• Mol file: 107836-75-9.mol

Synonyms:4,6-dichloronicotinoyl chloride

Chemical Property of 4,6-dichloronicotinoyl chloride

Chemical Property:

• Boiling Point: 271.8±35.0 °C(Predicted)
• PKA: -1.76±0.10(Predicted)
• PSA: 29.96000
• Density: 1.582±0.06 g/cm3(Predicted)
• LogP: 2.76740

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6-Dichloronicotinoylchloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-dichloronicotinoyl chloride

There total 5 articles about 4,6-dichloronicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,6-dichloro-nicotinic acid (73027-79-9) → 4,6-dichloropyridine-3-carbonyl chloride (107836-75-9)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; Reflux;

DOI:10.1016/j.tetlet.2010.11.112

Reference yield:

ethyl 4,6-dichloronicotinate (40296-46-6) → 4,6-dichloropyridine-3-carbonyl chloride (107836-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / Reflux

With thionyl chloride; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; water; toluene;

DOI:10.1016/j.tetlet.2010.11.112

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → 4,6-dichloropyridine-3-carbonyl chloride (107836-75-9)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride / 145 °C

2: trichlorophosphate / Reflux

3: lithium hydroxide / tetrahydrofuran; water / 20 °C

4: thionyl chloride; N,N-dimethyl-formamide / toluene / Reflux

With thionyl chloride; acetic anhydride; N,N-dimethyl-formamide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; water; toluene;

DOI:10.1016/j.tetlet.2010.11.112

upstream raw materials:

4,6-dichloro-nicotinic acid

ethyl 4,6-dichloronicotinate

4,6-dihydroxynicotinic acid ethyl ester

diethyl 1,3-acetonedicarboxylate

Downstream raw materials:

(2,6-dichloro-3-pyridinyl)[4-(methyloxy)phenyl]methanone

1-(4,6-dichloropyridin-3-yl)ethan-1-one

C₁₅H₁₅NO₂

4-methyl-6-phenyl-nicotinic acid

Refernces

• 1、 -. "HETEROARYL SULFONAMIDE COMPOUND AND FORMULATION FOR CONTROLLING HARMFUL ORGANISMS". Paragraph 0440-0444. . Retrieved 2021/02/05.
• 2、 -. "AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CONDITIONS RELATED TO THE MODULATION OF IL-12, IL-23 AND/OR IFN-ALPHA". Page/Page column 257. . Retrieved 2020/05/29.