40296-46-6

Basic information

• Product Name: Ethyl 4,6-dichloronicotinate
• Synonyms: 4,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;4,6-DICHLORONICOTINIC ACID ETHYL ESTER;ETHYL 4,6-DICHLORONICOTINATE;2,4-Dichloro-5-carbethoxypyridine;4,6-Dichloronicotinic acid ethyl ester ,97%;ethyl 4,6-dichloronicotinate (en);Ethyl 4,6-dichloronicotinate ,97%;ethyl 4,6-dichloropyridine-3-carboxylate
• CAS NO: 40296-46-6
• Molecular Formula: C₈H₇Cl₂NO₂
• Molecular Weight: 220.05
• Product Categories: Pyridine series;Boronic Acid
• Mol File: 40296-46-6.mol
• Article Data: 33

Chemical Properties

• Melting Point: 32-34°
• Boiling Point: 85°C/0.01mmHg(lit.)
• Flash Point: 120.9 °C
• Appearance: Yellow/Liquid
• Density: 1.367 g/cm³
• Vapor Pressure: 0.00484mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Soluble in methanol.
• PKA: -1.24±0.10(Predicted)
• CAS DataBase Reference: Ethyl 4,6-dichloronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4,6-dichloronicotinate(40296-46-6)
• EPA Substance Registry System: Ethyl 4,6-dichloronicotinate(40296-46-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 40296-46-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 40296-46-6 differently. You can refer to the following data:
1. Ethyl 4,6-Dichloronicotinate acts as a reactant in the preparation of (acylamino)aminonaphthyridinones as novobiocin analogs and Hsp90 inhibitors, their antitumor activities in human breast cancer cell lines, and the effects on aptoptosis and cell cycle advancement of selected compounds.
2. Ethyl 4,6-dichloronicotinate, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as a fine chemical intermediate.

Chemical Properties

White solid

InChI:InChI=1/C8H7Cl2NO2/c1-2-13-8(12)5-4-11-7(10)3-6(5)9/h3-4H,2H2,1H3

Upstream product

• 73027-79-9 4,6-dichloro-nicotinic acid 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 107836-75-9 4,6-dichloropyridine-3-carbonyl chloride 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 6975-44-6 4-Hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 

Downstream Products

• 73027-79-9 4,6-dichloro-nicotinic acid 
• 845655-96-1 6-chloro-4-hydrazino-nicotinic acid ethyl ester 
• 55934-01-5 2,3,5-trichloropyridine 
• 166526-03-0 4,6-dichloropyridine-3-carbonitrile 
• 888482-53-9 4-(4-bromo-2-methyl-phenylamino)-6-chloro-nicotinic acid ethyl ester 
• 73998-95-5 2,4-dichloro-5-hydroxymethylpyridine 
• 107836-75-9 4,6-dichloropyridine-3-carbonyl chloride 
• 1417792-29-0 C₁₅H₁₅NO₂ 
• 29051-45-4 4-methyl-6-phenyl-nicotinic acid 
• 449811-30-7 (6-chloro-4-(methylamino)pyridin-3-yl)methanol 
• 449811-29-4 6-chloro-4-(methylamino)pyridine-3-carbaldehyde 
• 1013914-30-1 ethyl 4-chloro-6-(3-chlorophenyl)nicotinate 
• 1013914-13-0 ethyl 6-chloro-4-(2-chlorophenoxy)nicotinate 
• 1013914-05-0 ethyl 4-chloro-6-(3,5-difluorophenyl)nicotinate 

Relevant articles and documents

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