4-(1H-Pyrazol-1-yl)aniline

Base Information

• Chemical Name: 4-(1H-Pyrazol-1-yl)aniline
• CAS No.: 17635-45-9
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Hs Code.: 2933199090
• Mol file: 17635-45-9.mol

Synonyms:Pyrazole,1-(p-aminophenyl)- (6CI,8CI);1-(4-Aminophenyl)pyrazole;1-(4'-Aminophenyl)-1H-pyrazole;1-(p-Aminophenyl)pyrazole;4-(1H-Pyrazol-1-yl)aniline;4-(1H-Pyrazol-1-yl)benzenamine;4-1H-Pyrazol-1-ylphenylamine;[4-(Pyrazol-1-yl)phenyl]amine;

Chemical Property of 4-(1H-Pyrazol-1-yl)aniline

Chemical Property:

• Vapor Pressure: 0.000545mmHg at 25°C
• Melting Point: 54 °C
• Refractive Index: 1.641
• Boiling Point: 311.978 °C at 760 mmHg
• PKA: 4.03±0.10(Predicted)
• Flash Point: 142.479 °C
• PSA: 43.84000
• Density: 1.2 g/cm³
• LogP: 2.03570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-(1H-Pyrazol-1-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1H-Pyrazol-1-yl)aniline

There total 11 articles about 4-(1H-Pyrazol-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(4-nitrophenyl)pyrazole (3463-30-7) → 4-(1H-pyrazol-1-yl)aniline (17635-45-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;

DOI:10.1248/cpb.48.1935

Reference yield: 91.0%

NH-pyrazole (288-13-1) + 4-bromo-aniline (106-40-1) → 4-(1H-pyrazol-1-yl)aniline (17635-45-9)

Guidance literature:

With caesium carbonate; copper(I) oxide; In acetonitrile; at 82 ℃; for 42h;

DOI:10.1002/ejoc.200300709

Reference yield: 91.0%

→ 4-(1H-pyrazol-1-yl)aniline (17635-45-9)

Guidance literature:

upstream raw materials:

1-(4-nitrophenyl)pyrazole

NH-pyrazole

4-bromo-aniline

p-aminoiodobenzene

Downstream raw materials:

4-pyrazol-1-yl-benzonitrile

4-(1H-pyrazol-1-yl)phenyl isothiocyanate

1-isopropyl-7-[4-(pyrazol-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one

1-methyl-7-[4-(pyrazol-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one