4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one

Base Information

• Chemical Name: 4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one
• CAS No.: 953070-72-9
• Molecular Formula: C10H6BrF2NO
• Molecular Weight: 274.065
• Mol file: 953070-72-9.mol

Synonyms:2(1H)-quinolinone, 4-(bromomethyl)-7,8-difluoro-; 4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one

Chemical Property of 4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 362.982°C at 760 mmHg
• Flash Point: 173.325°C
• PSA: 32.86000
• Density: 1.684g/cm³
• LogP: 2.70120
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one

There total 3 articles about 4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-bromo-N-(2,3-difluorophenyl)-3-oxobutanamide (953071-01-7) → 4-(bromomethyl)-7,8-difluoroquinolin-2(1H)-one (953070-72-9)

Guidance literature:

With sulfuric acid; at 45 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm100828n

Reference yield:

2,3-difluoroanilline (4519-40-8) → 4-(bromomethyl)-7,8-difluoroquinolin-2(1H)-one (953070-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 5,5-dimethyl-1,3-cyclohexadiene / Reflux

2.1: bromine; acetic acid / 25 - 50 °C

2.2: 2 h / 25 °C

3.1: sulfuric acid / 40 °C

With pyridine; sulfuric acid; bromine; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.bmcl.2011.11.073

Reference yield:

N-(2,3-difluorophenyl)-3-oxobutanamide (1125702-46-6) → 4-(bromomethyl)-7,8-difluoroquinolin-2(1H)-one (953070-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine; acetic acid / 25 - 50 °C

1.2: 2 h / 25 °C

2.1: sulfuric acid / 40 °C

With sulfuric acid; bromine; acetic acid;

DOI:10.1016/j.bmcl.2011.11.073

upstream raw materials:

4-bromo-N-(2,3-difluorophenyl)-3-oxobutanamide

N-(2,3-difluorophenyl)-3-oxobutanamide

2,3-difluoroanilline

Downstream raw materials:

N-(3-chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)pyridine-3-sulfonamide

7,8-difluoro-4-((2-phenyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)quinolin-2(1H)-one

4-(((3-chlorophenyl)(pyridin-3-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one

N-(3-chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-1-methyl-1H-imidazole-5-carboxamide

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