CCT241533

Base Information

• Chemical Name: CCT241533
• CAS No.: 1262849-73-9
• Molecular Formula: C23H27FN4O4
• Molecular Weight: 442.48
• Mol file: 1262849-73-9.mol

Synonyms:CCT241533

Chemical Property of CCT241533

Chemical Property:

• Boiling Point: 569.4±50.0 °C(Predicted)
• PKA: 8.18±0.48(Predicted)
• PSA: 111.99000
• Density: 1.327
• LogP: 2.68020
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

CCT241533 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CCT241533 is an inhibitor of checkpoint kinase 2, which is a potential antitumor and radioprotectant.

Technology Process of CCT241533

There total 6 articles about CCT241533 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

C28H35FN4O6 → CCT241533 (1262849-73-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 24h;

DOI:10.1021/jm101150b

Reference yield:

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one (27631-29-4) → CCT241533 (1262849-73-9)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 96 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene / 24 h / 100 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 24 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; toluene; 2: Suzuki-Miyaura reaction;

DOI:10.1021/jm101150b

Reference yield:

1-tert-butyl 3-ethyl (3R,4S)-4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)pyrrolidine-1,3-dicarboxylate → CCT241533 (1262849-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene / 24 h / 100 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 24 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; toluene; 1: Suzuki-Miyaura reaction;

DOI:10.1021/jm101150b

upstream raw materials:

1-tert-butyl 3-ethyl (3R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxyquinazolin-4-ylamino)pyrrolidine-1,3-dicarboxylate

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

2,4-dihydroxy-6,7-dimethoxyquinazoline