1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel-

Base Information

Chemical Name:1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel-
CAS No.:1262849-80-8
Molecular Formula:
Molecular Weight:0
Hs Code.:
Mol file:1262849-80-8.mol

1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel-

Synonyms:1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel-

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of 1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel-

There total 3 articles about 1,3-Pyrrolidinedicarboxylic acid, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-diMethoxy-4-quinazolinyl]aMino]-, 1-(1,1-diMethylethyl) 3-ethyl ester, (3R,4S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 259209-20-6
5-fluoro-2-hydroxyphenyl-boronic acid

: 1-tert-butyl 3-ethyl (3R,4S)-4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)pyrrolidine-1,3-dicarboxylate

: 1262849-80-8
1-tert-butyl 3-ethyl (3R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxyquinazolin-4-ylamino)pyrrolidine-1,3-dicarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm101150b

Reference yield:

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 1262849-80-8
1-tert-butyl 3-ethyl (3R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxyquinazolin-4-ylamino)pyrrolidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 96 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene / 24 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In dichloromethane; water; toluene; 2: Suzuki-Miyaura reaction;
DOI:10.1021/jm101150b

Reference yield:

: 28888-44-0
2,4-dihydroxy-6,7-dimethoxyquinazoline

: 1262849-80-8
1-tert-butyl 3-ethyl (3R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxyquinazolin-4-ylamino)pyrrolidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 14 h / Reflux

2: triethylamine / dichloromethane / 96 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene / 24 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; trichlorophosphate; In dichloromethane; water; toluene; 3: Suzuki-Miyaura reaction;
DOI:10.1021/jm101150b