2-(3-Methoxy-phenyl)-2-Methyl-propionic acid Methyl ester

Base Information

• Chemical Name: 2-(3-Methoxy-phenyl)-2-Methyl-propionic acid Methyl ester
• CAS No.: 32454-33-4
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: 2918990090
• Mol file: 32454-33-4.mol

Synonyms:2-m-Methoxyphenyl-2-methylpropionsaeuremethylester;

Chemical Property of 2-(3-Methoxy-phenyl)-2-Methyl-propionic acid Methyl ester

Chemical Property:

• Boiling Point: 273.7±23.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.040±0.06 g/cm3(Predicted)
• LogP: 2.14580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl2-(3-methoxyphenyl)-2-methylpropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-Methoxy-phenyl)-2-Methyl-propionic acid Methyl ester

There total 8 articles about 2-(3-Methoxy-phenyl)-2-Methyl-propionic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-methoxyphenyl bromide (2398-37-0) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) → methyl 2-(3-methoxyphenyl)-2-methylpropanoate (32454-33-4)

Guidance literature:

With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 20 ℃; for 24h;

DOI:10.1021/ja027643u

Reference yield: 86.0%

3-methoxyphenyl bromide (2398-37-0) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) → methyl 2-(3-methoxyphenyl)-2-methylpropanoate (32454-33-4) + N,N-dicyclohexyl-3-methoxyaniline (1376242-53-3)

Guidance literature:

Methyl isobutyrate; With n-butyllithium; N-cyclohexyl-cyclohexanamine; In hexane; toluene; at 0 - 5 ℃; for 0.833333h;

3-methoxyphenyl bromide; With di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); In hexane; toluene; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.15227/orgsyn.088.0004

Reference yield: 81.0%

Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) + 3-methoxy-1-iodobenzene (766-85-8) → methyl 2-(3-methoxyphenyl)-2-methylpropanoate (32454-33-4)

Guidance literature:

Methyl isobutyrate; With 2,2,6,6-tetramethylpiperidinyl-lithium; In toluene; at 20 ℃; for 0.25h; Glovebox;

3-methoxy-1-iodobenzene; With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In toluene; at 20 ℃; chemoselective reaction; Glovebox;

DOI:10.1055/s-0037-1610087

upstream raw materials:

methyl (3-methoxyphenyl)acetate

methyl iodide

3-methoxyphenyl bromide

Methyl isobutyrate

Downstream raw materials:

2-(3-methoxyphenyl)-2-methyl-propan-1-ol

3-isopropylanisole

2-methyl-2-(m-methoxyphenyl)-1-propanal

2-(3-hydroxy-phenyl)-2-methyl-propionic acid methyl ester

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