1H-Pyrazolo[3,4-c]pyridin-3-amine

Base Information

• Chemical Name: 1H-Pyrazolo[3,4-c]pyridin-3-amine
• CAS No.: 76006-17-2
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80452008
• Nikkaji Number: J1.130.238F
• Wikidata: Q82272351
• Mol file: 76006-17-2.mol

Synonyms:1H-Pyrazolo[3,4-c]pyridin-3-amine;76006-17-2;SCHEMBL868303;AMY7669;DTXSID80452008;LGZRIKTZAOPKET-UHFFFAOYSA-N;BDA00617;MFCD11656373;2H-pyrazolo[3,4-c]pyridin-3-amine;1H-Pyrazolo[3,4-c]pyridine-3-amine;AKOS006338673;2H-Pyrazolo[3,4-c]pyridin-3-ylamine;SB75518;BL009413;BS-25958;CS-0187771;FT-0715964;1H-Pyrazolo[3,4-c]pyridin-3-amine, AldrichCPR;EN300-2905666;Z1203582635

Chemical Property of 1H-Pyrazolo[3,4-c]pyridin-3-amine

Chemical Property:

• Melting Point: 213-214 °C(Solv: ethanol (64-17-5))
• Boiling Point: 433.5±25.0 °C(Predicted)
• PKA: 11.83±0.40(Predicted)
• PSA: 67.59000
• Density: 1.480±0.06 g/cm3(Predicted)
• LogP: 1.12130
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 134.059246208
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

97% ^*data from raw suppliers

1H-Pyrazolo[3,4-c]pyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1C(=NN2)N

Technology Process of 1H-Pyrazolo[3,4-c]pyridin-3-amine

There total 8 articles about 1H-Pyrazolo[3,4-c]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-4-pyridinecarbonitrile (113770-88-0) → 1H-pyrazolo[3,4-c]pyridin-3-amine (76006-17-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 70 ℃; for 16h;

Reference yield: 87.0%

3-Azido-4-cyanopyridine (78790-80-4) → 1H-pyrazolo[3,4-c]pyridin-3-amine (76006-17-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1080/00304949709355235

Reference yield: 61.0%

3-Nitro-1H-pyrazolo<3,4-c>pyridine (76006-15-0) → 1H-pyrazolo[3,4-c]pyridin-3-amine (76006-17-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 1520 Torr;

upstream raw materials:

3-Nitro-1H-pyrazolo<3,4-c>pyridine

3-Azido-4-cyanopyridine

1H-pyrazolo[3,4-c]pyridine

3-bromo-4-cyanopyridine

Downstream raw materials:

3-cyano-1H-pyrazolo[3,4-c]pyridine

3-bromo-1H-pyrazolo[3,4-c]pyridine