5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 898747-24-5
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.071
• Hs Code.: 2933990090
• Mol file: 898747-24-5.mol

Synonyms:5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER;Methyl 5-bromo-1H-indazole-7-carboxylate;1H-Indazole-7-carboxylic acid, 5-broMo-, Methyl ester;5-Bromo-7-(methoxycarbonyl)-1H-indazole;ethyl 5-broMo-1H-indazole-7-carboxylate

Chemical Property of 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 54.98000
• LogP: 2.11200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl 5-bromo-1H-indazole-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER

There total 10 articles about 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C11H9BrN2O3 (1549643-27-7) → methyl 5-bromo-1H-indazole-7-carboxylate (898747-24-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.12.033

Reference yield: 98.0%

acetic anhydride (108-24-7) + 2-Amino-5-bromo-3-methyl-benzoic acid methyl ester (206548-14-3) → methyl 5-bromo-1H-indazole-7-carboxylate (898747-24-5)

Guidance literature:

acetic anhydride; 2-Amino-5-bromo-3-methyl-benzoic acid methyl ester; With potassium acetate; In chloroform; at 0 - 20 ℃; for 0.25h;

With 18-crown-6 ether; isopentyl nitrite; In chloroform; at 65 ℃; for 18h;

Reference yield: 88.0%

2-Amino-5-bromo-3-methyl-benzoic acid methyl ester (206548-14-3) → methyl 5-bromo-1H-indazole-7-carboxylate (898747-24-5)

Guidance literature:

2-Amino-5-bromo-3-methyl-benzoic acid methyl ester; With acetic anhydride; In chloroform;

With potassium acetate; isopentyl nitrite; In chloroform; Reflux;

DOI:10.1016/j.bmcl.2014.03.074

upstream raw materials:

C₁₁H₁₂BrNO₃

acetic anhydride

2-Amino-5-bromo-3-methyl-benzoic acid methyl ester

isopentyl nitrite

Downstream raw materials:

5-bromo-1H-indazole-7-carboxamide

(5-bromo-1H-indazol-7-yl)methanol

Refernces

• 1、 -. "ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS". Page/Page column 474; 475. . Retrieved 2018/09/21.
• 2、 -. "2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE". Paragraph 0394. . Retrieved 2015/11/27.