1H-Indazole-4-carboxylic acid, 5-bromo-, methyl ester

Base Information

• Chemical Name: 1H-Indazole-4-carboxylic acid, 5-bromo-, methyl ester
• CAS No.: 1037840-79-1
• Molecular Formula: C9H7BrN2O2
• Molecular Weight: 255.07
• Hs Code.: 2933990090
• Mol file: 1037840-79-1.mol

Synonyms:1H-Indazole-4-carboxylic acid, 5-broMo-, Methyl ester

Chemical Property of 1H-Indazole-4-carboxylic acid, 5-bromo-, methyl ester

Chemical Property:

• Boiling Point: 391.9±22.0 °C(Predicted)
• PKA: 11.17±0.40(Predicted)
• PSA: 54.98000
• Density: 1.709±0.06 g/cm3(Predicted)
• LogP: 2.11200
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Bromo-1H-indazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-4-carboxylic acid, 5-bromo-, methyl ester

There total 2 articles about 1H-Indazole-4-carboxylic acid, 5-bromo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 3-amino-6-bromo-2-methylbenzoate (750586-06-2) → methyl 5-bromo-1H-indazole-4-carboxylate (1037840-79-1)

Guidance literature:

methyl 3-amino-6-bromo-2-methylbenzoate; With acetic acid; sodium nitrite; In water; at 10 - 35 ℃;

With sodium hydrogencarbonate; In water;

Reference yield:

methyl 3-amino-2-methylbenzoate (18583-89-6) → methyl 5-bromo-1H-indazole-4-carboxylate (1037840-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine; sodium thiosulfate / methanol; water / 0 °C

2: acetic acid; sodium nitrite / water / 3 h / 10 - 35 °C

With bromine; sodium thiosulfate; acetic acid; sodium nitrite; In methanol; water;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 5-bromo-1H-indazole-4-carboxylate (1037840-79-1) → 1-tert-butyl 4-methyl 5-bromo-1H-indazole-1,4-dicarboxylate

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 10 - 35 ℃; for 3h;

upstream raw materials:

methyl 3-amino-6-bromo-2-methylbenzoate

methyl 3-amino-2-methylbenzoate