Silvestrol

Base Information

• Chemical Name: Silvestrol
• CAS No.: 697235-38-4
• Molecular Formula: C34H38O13
• Molecular Weight: 654.668
• UNII: KK3Y3KN5BV
• ChEMBL ID: CHEMBL555196
• DSSTox Substance ID: DTXSID601028120
• Metabolomics Workbench ID: 142632
• Pharos Ligand ID: SFLSKLDRFWF9
• Wikidata: Q27135085
• Wikipedia: Silvestrol
• Mol file: 697235-38-4.mol

Synonyms:silvestrol

Chemical Property of Silvestrol

Chemical Property:

• Melting Point: 120-122℃
• Boiling Point: 800.8±65.0 °C(Predicted)
• PKA: 11.57±0.70(Predicted)
• PSA: 171.83000
• Density: 1.45
• LogP: 1.57280
• Solubility.: Soluble in DMSO
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 11
• Exact Mass: 654.23124126
• Heavy Atom Count: 47
• Complexity: 1050

Purity/Quality:

97% ^*data from raw suppliers

Silvestrol 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1C(OC(CO1)C(CO)O)OC2=CC3=C(C(=C2)OC)C4(C(C(C(C4(O3)C5=CC=C(C=C5)OC)C6=CC=CC=C6)C(=O)OC)O)O
• Isomeric SMILES: CO[C@H]1[C@@H](O[C@H](CO1)[C@@H](CO)O)OC2=CC3=C(C(=C2)OC)[C@@]4([C@@H]([C@@H]([C@H]([C@@]4(O3)C5=CC=C(C=C5)OC)C6=CC=CC=C6)C(=O)OC)O)O

Technology Process of Silvestrol

There total 7 articles about Silvestrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C48H44N2O19 → (1R,2R,3S,3aR,8bS)-methyl 6-(((2S,3R,6R)-6-((R)-1,2-dihydroxyethyl)-3-methoxy-1,4-dioxan-2-yl)oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate (697235-38-4)

Guidance literature:

C₄₈H₄₄N₂O₁₉; With methanol; sodium methylate; at 20 ℃; for 0.25h;

With Amberlite; In methanol; pH=7;

Reference yield: 90.4%

methyl (1R,2R,3S,3aR,8bS)-6-(((2S,3R,6R)-6-((R)-2-((tert-butyldimethylsilyl)oxy)-1-(((4-nitrophenoxy)carbonyl)oxy)ethyl)-3-methoxy-1,4-dioxan-2-yl)oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate → (1R,2R,3S,3aR,8bS)-methyl 6-(((2S,3R,6R)-6-((R)-1,2-dihydroxyethyl)-3-methoxy-1,4-dioxan-2-yl)oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate (697235-38-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 12h;

Reference yield: 87.0%

C48H50O13 (960365-79-1) → (1R,2R,3S,3aR,8bS)-methyl 6-(((2S,3R,6R)-6-((R)-1,2-dihydroxyethyl)-3-methoxy-1,4-dioxan-2-yl)oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate (697235-38-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In tetrahydrofuran; ethanol; for 0.75h;

DOI:10.1002/anie.200702707

upstream raw materials:

C₄₈H₅₀O₁₃

4-nitro-benzoic acid

5'''-episilvestrol

(1R,2R,3S,3aR,8bS)-methyl 1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]-cyclopenta[d]furan-2-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 697235-38-4 (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send