Methyl 2,6-dimethoxynicotinate

Base Information

• Chemical Name: Methyl 2,6-dimethoxynicotinate
• CAS No.: 65515-26-6
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.187897
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90443705
• Nikkaji Number: J1.403.922H
• Wikidata: Q82261619
• Mol file: 65515-26-6.mol

Synonyms:Methyl 2,6-dimethoxynicotinate;65515-26-6;Methyl 2,6-dimethoxypyridine-3-carboxylate;MFCD15144586;Methyl2,6-dimethoxynicotinate;SCHEMBL11605385;DTXSID90443705;UFHAKDJNDMIPMV-UHFFFAOYSA-N;AKOS015892434;FF-0720;2,6-dimethoxy-nicotinic acid methylester;SY102639;FT-0683883;A867654;J-521905;2,6-Dimethoxy-3-pyridinecarboxylic acid methyl ester

Chemical Property of Methyl 2,6-dimethoxynicotinate

Chemical Property:

• PSA: 57.65000
• LogP: 0.88540
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 197.06880783
• Heavy Atom Count: 14
• Complexity: 197

Purity/Quality:

97% ^*data from raw suppliers

Methyl2,6-dimethoxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)C(=O)OC)OC

Technology Process of Methyl 2,6-dimethoxynicotinate

There total 8 articles about Methyl 2,6-dimethoxynicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

→ methyl 2,6-dimethoxypyridine-3-carboxylate (65515-26-6)

Guidance literature:

Reference yield:

sodium methylate (124-41-4) + methyl 2,6-difluoro-3-pyridinecarboxylate (117671-02-0) → methyl 2,6-dimethoxypyridine-3-carboxylate (65515-26-6) + methyl 2-fluoro-6-methoxypyridine-3-carboxylate (117671-03-1) + methyl 6-fluoro-2-methoxypyridine-3-carboxylate (325707-62-8)

Guidance literature:

In tetrahydrofuran; at 5 ℃; for 0.166667h;

DOI:10.1248/cpb.48.1847

Reference yield:

sodium methylate (124-41-4) + methyl 2,6-dichloronicotinate (65515-28-8) → methyl 6-chloro-2-methoxypyridine-3-carboxylate (65515-32-4) + methyl 2,6-dimethoxypyridine-3-carboxylate (65515-26-6) + methyl 2-chloro-6-methoxypyridine-3-carboxylate (95652-77-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1248/cpb.48.1847

upstream raw materials:

sodium methylate

methyl 2,6-difluoro-3-pyridinecarboxylate

methyl 2,6-dichloronicotinate

2,6-dichloropyridine-3-carboxylic acid

Downstream raw materials:

2,6-dimethoxynicotinic acid ethyl ester