Imidazo[1,2-a]pyridine-3-boronic acid pinacol ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-3-boronic acid pinacol ester
• CAS No.: 942070-78-2
• Molecular Formula: C13H17BN2O2
• Molecular Weight: 244.101
• Hs Code.: 2934999090
• Mol file: 942070-78-2.mol

Synonyms:IMIDAZO[1,2-A]PYRIDINE-3-BORONIC ACID PINACOL ESTER;IMidazo[1,2-a]pyridine,3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

Chemical Property of Imidazo[1,2-a]pyridine-3-boronic acid pinacol ester

Chemical Property:

• PKA: 6.82±0.50(Predicted)
• PSA: 35.76000
• Density: 1.12
• LogP: 1.63350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Imidazo[1,2-a]pyridine-3-boronic Acid Pinacol Ester is used in the preparation and invention of 3-Tetrazolylbenzene-1,2-disulfonamide derivatives as metallo-beta-lactamase inhibitors for the treatment of bacterial infections.

Technology Process of Imidazo[1,2-a]pyridine-3-boronic acid pinacol ester

There total 2 articles about Imidazo[1,2-a]pyridine-3-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine (942070-78-2)

Guidance literature:

Reference yield:

imidazo[1,2-a]pyridine (274-76-0) + bis(pinacol)diborane (73183-34-3) → 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine (942070-78-2)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tert-butyl methyl ether; at 80 ℃; Glovebox;

DOI:10.1002/ejoc.201900608

Reference yield:

4-(5-bromo-thiazol-2-ylamino)-benzoic acid ethyl ester (923946-97-8) + 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine (942070-78-2) → C19H16N4O2S

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

imidazo[1,2-a]pyridine

bis(pinacol)diborane

Downstream raw materials:

3-(3-methoxyphenyl)imidazo[1,2-a]pyridine

Refernces

• 1、 -. "Process for producing oxazole, imidazole, pyrrazole boryl compounds". Page/Page column 6. . Retrieved 2010/11/30.