toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester
• CAS No.: 263400-88-0
• Molecular Formula: C11H16O5S2
• Molecular Weight: 292.377
• Mol file: 263400-88-0.mol

Synonyms:toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester;3-(Methylsulfonyl)propyl 4-Methylbenzenesulfonate;ALG-1A78317;3-(Methylsulfonyl)propyl tosylate;toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester-3

Chemical Property of toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester

Chemical Property:

• Boiling Point: 510.7±33.0 °C(Predicted)
• PSA: 94.27000
• Density: 1.302±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 3.29660
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

3-(Methylsulfonyl)propyl 4-methylbenzenesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester

There total 5 articles about toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(methylthio)-1-propanol mono-p-toluenesulfonate (187722-18-5) → 3-(methylsulfonyl)propyl 4-methylbenzenesulfonate (263400-88-0)

Guidance literature:

With Oxone; In methanol; water; at 0 - 20 ℃; for 3h;

Reference yield: 83.0%

3-(methylsulfonyl)propan-1-ol (2058-49-3) + p-toluenesulfonyl chloride (98-59-9) → 3-(methylsulfonyl)propyl 4-methylbenzenesulfonate (263400-88-0)

Guidance literature:

With triethylamine; In dichloromethane; for 12h; Inert atmosphere;

Reference yield: 82.0%

3-(methylthio)-1-propanol (505-10-2) + p-toluenesulfonyl chloride (98-59-9) → 3-(methylsulfonyl)propyl 4-methylbenzenesulfonate (263400-88-0)

Guidance literature:

3-(methylthio)-1-propanol; p-toluenesulfonyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 20 ℃; for 2h;

upstream raw materials:

3-(methylthio)-1-propanol mono-p-toluenesulfonate

p-toluenesulfonyl chloride

3-(methylsulfonyl)propan-1-ol

3-(methylthio)-1-propanol

Downstream raw materials:

2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-carbaldehyde

2-{[3-(Methylsulfonyl)propyl]sulfanyl}-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

3-[4-(Cyclopropylmethoxy)phenyl]-2-{[3-(methylsulfonyl)propyl]sulfanyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

2-{[3-(methylsulfonyl)propyl]sulfanyl}-3-{4-[(2,2,2-trifluoroethoxy)methyl]phenyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one