Ethyl 2-(3-bromopyridin-2-YL)acetate

Base Information

• Chemical Name: Ethyl 2-(3-bromopyridin-2-YL)acetate
• CAS No.: 197376-41-3
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.088
• DSSTox Substance ID: DTXSID40571547
• Nikkaji Number: J963.653F
• Wikidata: Q72511833
• Mol file: 197376-41-3.mol

Synonyms:ETHYL 2-(3-BROMOPYRIDIN-2-YL)ACETATE;197376-41-3;Ethyl 2-(3-Bromo-2-pyridyl)acetate;2-Pyridineacetic acid, 3-bromo-, ethyl ester;MFCD10566269;(3-Bromo-pyridin-2-yl)-acetic acid ethyl ester;SCHEMBL4882694;DTXSID40571547;XHA37641;Ethyl (3-bromopyridin-2-yl)acetate;Ethyl2-(3-Bromo-2-pyridyl)acetate;CK2612;AKOS015995491;SB21119;AM807654;DS-16506;SY025618;CS-0041501;(3-BroMopyridin-2-yl)acetic acid ethyl ester;EN300-26504;A880042

Chemical Property of Ethyl 2-(3-bromopyridin-2-YL)acetate

Chemical Property:

• Boiling Point: 278℃
• Flash Point: 122℃
• Density: 1.451
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.98949
• Heavy Atom Count: 13
• Complexity: 175

Purity/Quality:

97% ^*data from raw suppliers

ethyl2-(3-bromopyridin-2-yl)acetate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=C(C=CC=N1)Br

Technology Process of Ethyl 2-(3-bromopyridin-2-YL)acetate

There total 1 articles about Ethyl 2-(3-bromopyridin-2-YL)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.62%

3-bromo-2-picoline (38749-79-0) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-(3-bromopyridin-2-yl)acetate (197376-41-3)

Guidance literature:

3-bromo-2-picoline; With lithium hexamethyldisilazane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Diethyl carbonate; at 0 ℃;

Reference yield: 85.42%

ethyl 2-(3-bromopyridin-2-yl)acetate (197376-41-3) → 2-(3-bromopyridin-2-yl)acetaldehyde

Guidance literature:

With diisobutylaluminium hydride; at -78 ℃; Inert atmosphere;

Reference yield: 81.8%

zinc(II) cyanide (557-21-1) + ethyl 2-(3-bromopyridin-2-yl)acetate (197376-41-3) → ethyl 2-(3-cyanopyridin-2-yl)acetate (86369-48-4)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 16h; Inert atmosphere;

upstream raw materials:

3-bromo-2-picoline

Diethyl carbonate

Downstream raw materials:

C₁₂H₁₅NO₂