86369-48-4Relevant articles and documents
METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS
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Paragraph 1319-1320, (2021/11/06)
The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
A versatile annulation route to primary-amino-substituted naphthyridine esters
Chen, Jinhua,Xu, Zijin,Wang, Tao,Lyssikatos, Joseph P.,Ndubaku, Chudi O.
, p. 89 - 92 (2014/01/06)
A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyano-pyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of -primary-amino-substituted 7-azaquinoxaline was also described. Georg Thieme Verlag Stuttgart · New York.
STUDIES ON SRN1 REACTIONS. PART 8 NEW AND DIRECT ARYLATION AND HETARYLATION OF β-DICARBONYL COMPOUNDS BY SRN1
Beugelmans, R.,Bois-Choussy, M.,Boudet, B.
, p. 3479 - 3483 (2007/10/02)
Arylation of β-dicarbonyl compounds is carried out by photostimulated SRN1 reaction between bromobenzonitriles or bromocyanopyridine and β-dicarbonyl derived monoanions.
