2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene

Base Information

• Chemical Name: 2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene
• CAS No.: 1017779-51-9
• Molecular Formula: C9H9BrF2O
• Molecular Weight: 251.071
• Hs Code.: 2909309090
• Mol file: 1017779-51-9.mol

Synonyms:4-ETHOXY-2,6-DIFLUOROBENZYL BROMIDE;

Chemical Property of 2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene

Chemical Property:

• Boiling Point: 230℃
• Flash Point: 115℃
• PSA: 9.23000
• Density: 1.495
• LogP: 3.25840
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98.5% ^*data from raw suppliers

2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Ethoxy-2,6-difluorobenzyl bromide, is used as an intermediate.

Technology Process of 2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene

There total 1 articles about 2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethoxy-2,6-difluoro-benzylalcohol (438050-23-8) → 2-(bromomethyl)-5-ethoxy-1,3-difluorobenzene (1017779-51-9)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.11.115

Reference yield: 89.0%

2-(bromomethyl)-5-ethoxy-1,3-difluorobenzene (1017779-51-9) + ethyl 5-cyclopropyl-4-methyl-1H-pyrazole-3-carboxylate (1445831-52-6) → ethyl 5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazole-3-carboxylate (1445831-55-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 85.0%

2-(bromomethyl)-5-ethoxy-1,3-difluorobenzene (1017779-51-9) + methyl 1H-indazole-3-carboxylate (43120-28-1) → methyl 1-[(4-ethoxy-2,6-difluorophenyl)methyl]-1H-indazole-3-carboxylate

Guidance literature:

methyl 1H-indazole-3-carboxylate; With caesium carbonate; In tetrahydrofuran; at 5 ℃; for 0.25h;

2-(bromomethyl)-5-ethoxy-1,3-difluorobenzene; In tetrahydrofuran; at 5 ℃;

upstream raw materials:

4-ethoxy-2,6-difluoro-benzylalcohol

Downstream raw materials:

C₁₀H₉F₂NO

ethyl 5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazole-3-carboxylate

2-{1-[(4-ethoxy-2,6-difluorophenyl)methyl]-1H-indazol-3-yl}-5-methoxypyrimidin-4-amine

Refernces