6-Hydroxy-7-methyl-1(2H)-isoquinolinone

Base Information

• Chemical Name: 6-Hydroxy-7-methyl-1(2H)-isoquinolinone
• CAS No.: 940890-82-4
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.187
• Hs Code.: 2933790090
• Mol file: 940890-82-4.mol

Synonyms:6-Hydroxy-7-methyl-1(2H)-isoquinolinone;6-Hydroxy-7-Methylisoquinolin-1(2H)-one

Chemical Property of 6-Hydroxy-7-methyl-1(2H)-isoquinolinone

Chemical Property:

• PSA: 53.09000
• LogP: 1.54210
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

6-hydroxy-7-methyl-1(2H)-Isoquinolinone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxy-7-methyl-1(2H)-isoquinolinone

There total 5 articles about 6-Hydroxy-7-methyl-1(2H)-isoquinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-Methoxy-7-methyl-2H-isoquinolin-1-one (209286-01-1) → 6-hydroxy-7-methyl-2H-isoquinolin-1-one (940890-82-4)

Guidance literature:

6-Methoxy-7-methyl-2H-isoquinolin-1-one; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 24h;

With ammonia; water; In dichloromethane; at 0 ℃; pH=9;

Reference yield:

3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester (940890-71-1) → 6-hydroxy-7-methyl-2H-isoquinolin-1-one (940890-82-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide

2: diphenylphosphoranyl azide; triethylamine / toluene

3: Diphenylmethane / 250 °C

4: boron tribromide

With Diphenylmethane; diphenylphosphoranyl azide; boron tribromide; triethylamine; sodium hydroxide; In toluene;

DOI:10.1016/j.bmcl.2010.12.104

Reference yield:

3-methoxy-4-methylbenzaldehyde (24973-22-6) → 6-hydroxy-7-methyl-2H-isoquinolin-1-one (940890-82-4)

Guidance literature:

Multi-step reaction with 5 steps

1: toluene

2: sodium hydroxide

3: diphenylphosphoranyl azide; triethylamine / toluene

4: Diphenylmethane / 250 °C

5: boron tribromide

With Diphenylmethane; diphenylphosphoranyl azide; boron tribromide; triethylamine; sodium hydroxide; In toluene;

DOI:10.1016/j.bmcl.2010.12.104

upstream raw materials:

6-Methoxy-7-methyl-2H-isoquinolin-1-one

C₁₁H₁₁NO₂

3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester

3-methoxy-4-methylbenzaldehyde

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