Benzamide, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,N-diethyl-

Base Information

Chemical Name:Benzamide, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,N-diethyl-
CAS No.:721448-74-4
Molecular Formula:C17H29NO2Si
Molecular Weight:307.508
Hs Code.:
Mol file:721448-74-4.mol

Synonyms:2-(tert-Butyl-dimethyl-silanyloxy)-N,N-diethyl-benzamide;

Suppliers and Price of Benzamide, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,N-diethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,N-diethyl-

Chemical Property:

PSA：29.54000
LogP:4.55260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Benzamide, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,N-diethyl-

There total 1 articles about Benzamide, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,N-diethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 19311-91-2
N,N-diethylsalicylamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 721448-74-4
2-{[tert-butyl(dimethyl)silyl]oxy}-N,N-diethylbenzamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2004.02.097

Reference yield: 83.0%

: 721448-74-4
2-{[tert-butyl(dimethyl)silyl]oxy}-N,N-diethylbenzamide

: 914298-83-2
2-bromo-6-{[tert-butyl(dimethyl)silyl]oxy}-N,N-diethylbenzamide

Guidance literature:: 2-{[tert-butyl(dimethyl)silyl]oxy}-N,N-diethylbenzamide; With n-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

With bromine; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 20.5h; Product distribution / selectivity;

Reference yield:

: 721448-74-4
2-{[tert-butyl(dimethyl)silyl]oxy}-N,N-diethylbenzamide

: benzoic acid 1-(tert-butyl-dimethyl-silanyloxymethyl)-4-dodecyloxy-3-oxo-1,3-dihydro-isobenzofuran-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: s-BuLi; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran / 1.5 h / -40 °C

1.2: tetrahydrofuran / 17 h / -40 - -30 °C

1.3: NaH / tetrahydrofuran / 3 h / 70 °C

2.1: K₂CO₃ / methanol / 3 h / 70 °C

3.1: 85 percent / K₂CO₃ / acetone / 19 h / 20 °C

4.1: 94 percent / HF*Py / pyridine; CH₂Cl₂ / 20 °C

5.1: imidazole / dimethylformamide / 2 h / 0 °C

6.1: pyridine / 20 °C

7.1: H₂ / Pd/C / 20 °C

8.1: DEAD; PPh₃ / tetrahydrofuran / 20 °C

With pyridine; 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; potassium carbonate; pyridine hydrogenfluoride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 8.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2004.02.097