3-Ethyl-1H-pyrazole-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-Ethyl-1H-pyrazole-5-carboxylic acid ethyl ester
• CAS No.: 885319-49-3
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.195
• Mol file: 885319-49-3.mol

Synonyms:3-ETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;AKOS PAO-0841;Ethyl 3-ethyl-1H-pyrazole-5-carboxylate

Chemical Property of 3-Ethyl-1H-pyrazole-5-carboxylic acid ethyl ester

Chemical Property:

• PSA: 54.98000
• LogP: 1.14880

Purity/Quality:

98% purity ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethyl-1H-pyrazole-5-carboxylic acid ethyl ester

There total 2 articles about 3-Ethyl-1H-pyrazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diazoacetic acid ethyl ester (623-73-4) + butyraldehyde (123-72-8) → 5-ethyl-1H-pyrazole-3-carboxylic acid ethyl ester (26308-40-7,885319-49-3)

Guidance literature:

With diethylamine; In dimethyl sulfoxide; at 20 ℃; for 24h; regioselective reaction;

DOI:10.1002/chem.201300047

Reference yield:

ethyl-2,4-dioxohexanoate (13246-52-1) → 5-ethyl-1H-pyrazole-3-carboxylic acid ethyl ester (26308-40-7,885319-49-3)

Guidance literature:

With hydrazine hydrochloride; In tetrahydrofuran; ethanol; water; at 75 ℃; for 1h;

DOI:10.1016/j.bmcl.2007.07.101

upstream raw materials:

ethyl-2,4-dioxohexanoate

diazoacetic acid ethyl ester

butyraldehyde