3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

Base Information

Chemical Name:3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile
CAS No.:1034474-19-5
Molecular Formula:C21H12Cl2N6O
Molecular Weight:435.27
Hs Code.:
Mol file:1034474-19-5.mol

Synonyms:3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile;-((1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yl)oxy)-5-chlorobenzonitrile

Suppliers and Price of 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

Chemical Property:

PSA：92.41000
LogP:5.32668

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

There total 24 articles about 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1034474-33-3
3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

: 1034474-19-5
3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.166667h; Product distribution / selectivity;

Reference yield:

: 1034474-31-1
4-(3-bromo-5-chlorophenoxy)-5-chloro-1H-indazole

: 1034474-19-5
3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm2010173

Reference yield:

: 1034474-29-7
3-bromo-5-chlorophenyl 2-chloro-5-fluorophenyl ether

: 1034474-19-5
3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 96 h / 95 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4.2: 0.17 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/jm2010173