3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Base Information

Chemical Name:3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile
CAS No.:1034474-33-3
Molecular Formula:C₂₆H₂₀Cl₂N₆O₃
Molecular Weight:535.389
Hs Code.:

Synonyms:3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

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Chemical Property of 3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

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Technology Process of 3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

There total 17 articles about 3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1034474-32-2
3-chloro-5-[(5-chloro-1H-indazol-4-yl)oxy]benzonitrile

: 174180-76-8
3-bromomethylpyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester

: 1034474-33-3
3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 1034474-30-0
2-(3-bromo-5-chlorophenoxy)-3-chloro-6-fluorobenzaldehyde

: 1034474-33-3
3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / dimethyl sulfoxide / 31.33 h / 20 - 73 °C / Heating / reflux

2: bromine; zinc / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 5.25 h / 20 - 85 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 3.1 - 21 °C

With bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydrazine; zinc; palladium diacetate; triphenylphosphine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1034474-29-7
3-bromo-5-chlorophenyl 2-chloro-5-fluorophenyl ether

: 1034474-33-3
3-chloro-5-{[5-chloro-1-(1-t-butyloxycarbonyl-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.83 h / -76 - 1 °C

1.2: 1.08 h / -60 - -20 °C

2.1: hydrazine / dimethyl sulfoxide / 31.33 h / 20 - 73 °C / Heating / reflux

3.1: bromine; zinc / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 5.25 h / 20 - 85 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 3.1 - 21 °C

With n-butyllithium; bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; hydrazine; zinc; palladium diacetate; triphenylphosphine; In tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;