4-(difluoro(3,4,5-trifluorophenoxy)methyl)-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl

Base Information

• Chemical Name: 4-(difluoro(3,4,5-trifluorophenoxy)methyl)-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl
• CAS No.: 916156-32-6
• Molecular Formula: C30H22F8O
• Molecular Weight: 550.491
• Mol file: 916156-32-6.mol

Synonyms:4-[Difluoro(3,4,5-trifluorophenoxy)methyl]-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl

Chemical Property of 4-(difluoro(3,4,5-trifluorophenoxy)methyl)-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(difluoro(3,4,5-trifluorophenoxy)methyl)-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl

There total 5 articles about 4-(difluoro(3,4,5-trifluorophenoxy)methyl)-2',3,5-trifluoro-4''-pentyl-1,1':4',1''-terphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(4-pentylphenyl) o-fluorophenylboronic acid (163129-14-4) + 5-[4-chloro-(2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene → 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-2',3,5-trifluoro-4-pentyl-[1,1';4',1]terphenyl (916156-32-6)

Guidance literature:

With 5%-palladium/activated carbon; tetrabutylammomium bromide; triethylamine; XPhos; In N,N-dimethyl acetamide; water; toluene; at 20 - 99 ℃; for 4.58333h; Temperature; Autoclave; Inert atmosphere;

Reference yield:

4-bromodifluoromethyl-4''-n-pentyl-2',3,5-trifluoro-1,1',4',1''-terphenyl (1052241-45-8) + 3,4,5-trifluorophenol (99627-05-1) → 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-2',3,5-trifluoro-4-pentyl-[1,1';4',1]terphenyl (916156-32-6)

Guidance literature:

With potassium carbonate; In water; at 100 ℃;

DOI:10.1080/15421400903065200

Reference yield:

2',3,5-trifluoro-4''-n-pentyl-1,1',4'1''-terphenyl (857048-79-4) → 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-2',3,5-trifluoro-4-pentyl-[1,1';4',1]terphenyl (916156-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / -70 °C

2: potassium carbonate / water / 100 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; water;

DOI:10.1080/15421400903065200

upstream raw materials:

2',3,5-trifluoro-4''-n-pentyl-1,1',4'1''-terphenyl

4-bromodifluoromethyl-4''-n-pentyl-2',3,5-trifluoro-1,1',4',1''-terphenyl

3,4,5-trifluorophenol

3-fluoro-4-iodo-4'-n-pentylbiphenyl