Methyl 6-azaindole-3-carboxylate

Base Information

• Chemical Name: Methyl 6-azaindole-3-carboxylate
• CAS No.: 108128-12-7
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Hs Code.: 2933990090
• Mol file: 108128-12-7.mol

Synonyms:Methyl 6-azaindole-3-carboxylate;1H-Pyrrolo[2,3-c]pyridine-3-carboxylic acid methyl ester;Methyl 1H-pyrrolo[2,3-c]pyridine-3-carboxylate;Methyl 1H-pyrrolo[2,3-c]pyridine-3-carbo×ylate;6-Azaindole-3-carboxylic acid Methyl ester

Chemical Property of Methyl 6-azaindole-3-carboxylate

Chemical Property:

• Boiling Point: 365.1±22.0 °C(Predicted)
• PKA: 13.08±0.40(Predicted)
• PSA: 54.98000
• Density: 1.324
• LogP: 1.34950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl1H-Pyrrolo[2,3-c]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-azaindole-3-carboxylate

There total 1 articles about Methyl 6-azaindole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

[4-(3-aminomethyl-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-methanone dihydrochloride + sodium methylate (124-41-4) → methyl 1H-pyrrolo[2,3-c]pyridine-3-carboxylate (108128-12-7)

Guidance literature:

In methanol; for 2h;

Reference yield: 73.88%

methyl 1H-pyrrolo[2,3-c]pyridine-3-carboxylate (108128-12-7) → 1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid (67058-74-6)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 30 ℃; for 2h;

Reference yield:

methyl 1H-pyrrolo[2,3-c]pyridine-3-carboxylate (108128-12-7) → 1H-pyrrolo[2,3-c]pyridine-3-carbonyl chloride

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 30 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 25 °C

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

sodium methylate

Downstream raw materials:

1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid