1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

Base Information

• Chemical Name: 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid
• CAS No.: 77556-50-4
• Molecular Formula: C9H7N3O2
• Molecular Weight: 189.17
• Hs Code.: 2933990090
• European Community (EC) Number: 858-690-1
• ChEMBL ID: CHEMBL220743
• Mol file: 77556-50-4.mol

Synonyms:77556-50-4;1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid;1-(2-Pyridinyl)-1H-pyrazole-4-carboxylic acid;1-pyridin-2-ylpyrazole-4-carboxylic Acid;1-Pyridin-2-yl-1H-pyrazole-4-carboxylic acid;CHEMBL220743;MFCD08273467;1-(2-pyridyl)pyrazole-4-carboxylic acid;SCHEMBL2160119;KQBNORAXWCYKIR-UHFFFAOYSA-N;CDA55650;BDBM50370785;CS1287;AKOS000184470;BS-4030;AM20061505;BB 0219789;CS-0217717;FT-0761028;1-Pyridin-2-yl-1H-pyrazol-4-carboxylic acid;EN300-83170;1-(2-pyridyl)-1H-pyrazole-4-carboxylic acid;2-(pyrazol-1'-yl)pyridine-4'-carboxylic acid;1-(pyridin-2-yl)-1H-pyrazole-4-carboxylicacid;F8880-4682;Z317041818;1-(Pyridin-2-yl)-1H-pyrazole-4-carboxylic acid, AldrichCPR

Chemical Property of 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

Chemical Property:

• Melting Point: 182-183 °C(Solv: methanol (67-56-1))
• Boiling Point: 415.9±20.0 °C(Predicted)
• PKA: 3.48±0.10(Predicted)
• PSA: 68.01000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 0.96550
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 189.053826475
• Heavy Atom Count: 14
• Complexity: 222

Purity/Quality:

97% ^*data from raw suppliers

1-(Pyridin-2-yl)-1H-pyrazole-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)N2C=C(C=N2)C(=O)O

Technology Process of 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

There total 5 articles about 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate (171193-35-4) → 2-(pyrazol-1'-yl)pyridine-4'-carboxylic acid (77556-50-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 7h;

Reference yield:

2-chloropyridine (109-09-1) → 2-(pyrazol-1'-yl)pyridine-4'-carboxylic acid (77556-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Cs₂CO₃ / dimethylformamide / 140 °C

2: 90 percent / KOH / ethanol; H₂O

With potassium hydroxide; caesium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.08.017

Reference yield:

2-(pyrazol-1-yl)pyridine (25700-11-2) → 2-(pyrazol-1'-yl)pyridine-4'-carboxylic acid (77556-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / conc. H₂SO₄, conc. HNO₃ / 1.) 0 deg C - 5 deg C; 2.) 2 h, room temperature

2: 46 percent / cuprous cyanide / dimethylsulfoxide / 5 h / 150 °C

3: 10percent aq. NaOH / Heating

With sodium hydroxide; sulfuric acid; nitric acid; copper(l) cyanide; In dimethyl sulfoxide;

upstream raw materials:

4'-cyano-2-(pyrazol-1'-yl)pyridine

ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate

2-chloropyridine

2-(pyrazol-1-yl)pyridine

Downstream raw materials:

1-(pyridin-2-yl)-1H-pyrazol-4-amine