4-[(3-amino-6-bromo-4-quinolinyl)amino]-.alpha.,.alpha.-dimethyl-Benzeneacetonitrile

Base Information

Chemical Name:4-[(3-amino-6-bromo-4-quinolinyl)amino]-.alpha.,.alpha.-dimethyl-Benzeneacetonitrile
CAS No.:915019-52-2
Molecular Formula:C19H17BrN4
Molecular Weight:381.275
Hs Code.:2933499090
Mol file:915019-52-2.mol

Synonyms:2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile;2-[4-(3-amino-6-bromoquinolin-4-ylamino)phenyl]-2-methylpropionitrile;S14-0508;

Suppliers and Price of 4-[(3-amino-6-bromo-4-quinolinyl)amino]-.alpha.,.alpha.-dimethyl-Benzeneacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile
5mg
$ 80.00

Matrix Scientific
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile 95+%
250mg
$ 621.00

Matrix Scientific
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile 95+%
1g
$ 1378.00

Crysdot
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile 95+%
1g
$ 451.00

ChemScene
Benzeneacetonitrile,4-[(3-amino-6-bromo-4-quinolinyl)amino]-a,a-dimethyl-
1g
$ 800.00

ChemScene
Benzeneacetonitrile,4-[(3-amino-6-bromo-4-quinolinyl)amino]-a,a-dimethyl-
250mg
$ 320.00

ChemScene
Benzeneacetonitrile,4-[(3-amino-6-bromo-4-quinolinyl)amino]-a,a-dimethyl-
100mg
$ 192.00

Chemenu
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile 95%
1g
$ 426.00

American Custom Chemicals Corporation
2-(4-(3-AMINO-6-BROMOQUINOLIN-4-YLAMINO)PHENYL)-2-METHYLPROPANENITRILE 95.00%
5MG
$ 497.52

Alichem
2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile
1g
$ 495.95

Total 12 raw suppliers

Chemical Property of 4-[(3-amino-6-bromo-4-quinolinyl)amino]-.alpha.,.alpha.-dimethyl-Benzeneacetonitrile

Chemical Property:

Vapor Pressure:3.03E-11mmHg at 25°C
Boiling Point:528.2°C at 760 mmHg
Flash Point:273.3°C
PSA：74.73000
Density:1.458g/cm³
LogP:5.77848
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(4-((3-Amino-6-bromoquinolin-4-yl)amino)-phenyl)-2-methylpropanenitrile is used as a reagent in the preparation of imidazo quinoline derivatives, compounds that act as mammalian target of rapamycin (mTOR) an phosphatidylinositol 3-kinase (PI3K-kinase) inhibitors.

Technology Process of 4-[(3-amino-6-bromo-4-quinolinyl)amino]-.alpha.,.alpha.-dimethyl-Benzeneacetonitrile

There total 12 articles about 4-[(3-amino-6-bromo-4-quinolinyl)amino]-.alpha.,.alpha.-dimethyl-Benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 915019-51-1
2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

: 915019-52-2
2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile

Guidance literature:: With hydrogen; Raney Ni; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

Reference yield:

: 71825-51-9
4-(2-cyanoprop-2-yl)-1-nitrobenzene

: 915019-52-2
2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr

2: acetic acid / 2 h

3: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr

With hydrogen; Raney-Ni; In tetrahydrofuran; methanol; acetic acid;

Reference yield:

: 853908-50-6
6-bromo-3-nitroquinolin-4-ol

: 915019-52-2
2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 0.75 h / 120 °C

2: acetic acid / 2 h

3: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr

With hydrogen; trichlorophosphate; Raney-Ni; In acetic acid;