Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-

Base Information

• Chemical Name: Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-
• CAS No.: 915019-53-3
• Molecular Formula: C₂₀H₁₅BrN₄O
• Molecular Weight: 407.269
• Mol file: 915019-53-3.mol

Synonyms:2-[4-(8-B; 2-[4-(8-b; benzeneac; LogP

Chemical Property of Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-

Chemical Property:

• PKA: 10.95±0.20(Predicted)
• PSA: 74.47000
• Density: 1.508g/cm³
• LogP: 4.43068
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-(8-Bromo-2-oxo-2,3-dihydro-1H-imidazo-[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 95+% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

Useful:

Technology Process of Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-

There total 19 articles about Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

6-bromo-4-(4-(2-cyanopropan-2-yl)phenylamino)quinoline-3-carboxylic acid → 2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (915019-53-3)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; toluene; at 85 - 95 ℃; for 4h;

Reference yield: 60.0%

2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile (915019-52-2) + 4-Nitrophenyl chloroformate (7693-46-1) → 2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (915019-53-3)

Guidance literature:

Reference yield: 60.0%

2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile (915019-52-2) + bis(trichloromethyl) carbonate (32315-10-9) → 2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (915019-53-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

upstream raw materials:

2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile

trichloromethyl chloroformate

2-(4-aminophenyl)-2-methylpropionitrile

4-(2-cyanoprop-2-yl)-1-nitrobenzene

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