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2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-

Base Information Edit
  • Chemical Name:2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-
  • CAS No.:328956-38-3
  • Molecular Formula:C10H5F3N2O3
  • Molecular Weight:258.15
  • Hs Code.:
  • DSSTox Substance ID:DTXSID00582114
  • Wikidata:Q82473436
  • Mol file:328956-38-3.mol
2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-

Synonyms:328956-38-3;2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-;6-NITRO-4-(TRIFLUOROMETHYL)-1H-QUINOLIN-2-ONE;MFCD12828492;4-trifluoromethyl-6-nitroquinolinone;6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone;SCHEMBL1771140;DTXSID00582114;AKOS015951301;s11905;SY317086;6-Nitro-4-trifluoromethyl-1H-quinolin-2-one;G10412;6-NITRO-4-TRIFLUOROMETHYL-QUINOLIN-2-OL;A875492

Suppliers and Price of 2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Crysdot
  • 6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one 95+%
  • 1g
  • $ 265.00
  • Crysdot
  • 6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one 95+%
  • 25g
  • $ 2644.00
  • Crysdot
  • 6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one 95+%
  • 5g
  • $ 796.00
  • Crysdot
  • 6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one 95+%
  • 10g
  • $ 1322.00
  • Chemenu
  • 6-nitro-4-(trifluoromethyl)quinolin-2(3H)-one 95%
  • 10g
  • $ 1248.00
  • Chemenu
  • 6-nitro-4-(trifluoromethyl)quinolin-2(3H)-one 95%
  • 25g
  • $ 2496.00
  • Chemenu
  • 6-nitro-4-(trifluoromethyl)quinolin-2(3H)-one 95%
  • 1g
  • $ 251.00
  • Chemenu
  • 6-nitro-4-(trifluoromethyl)quinolin-2(3H)-one 95%
  • 5g
  • $ 752.00
  • Chemcia Scientific
  • 6-Nitro-4-trifluoromethyl-1H-quinolin-2-one >97%
  • 0.5 G
  • $ 195.00
  • American Custom Chemicals Corporation
  • 6-NITRO-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE 95.00%
  • 5MG
  • $ 496.11
Total 14 raw suppliers
Chemical Property of 2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)- Edit
Chemical Property:
  • Melting Point:284-285 °C(Solv: ethanol (64-17-5)) 
  • Boiling Point:368.7±42.0 °C(Predicted) 
  • PKA:9.09±0.70(Predicted) 
  • PSA:78.68000 
  • Density:1.564±0.06 g/cm3(Predicted) 
  • LogP:2.97830 
  • Storage Temp.:Sealed in dry,Room Temperature 
  • XLogP3:1.6
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:0
  • Exact Mass:258.02522651
  • Heavy Atom Count:18
  • Complexity:414
Purity/Quality:

97% *data from raw suppliers

6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one 95+% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC2=C(C=C1[N+](=O)[O-])C(=CC(=O)N2)C(F)(F)F
  • Uses 6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of LGD-2226 (L397615), an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.
Technology Process of 2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-

There total 3 articles about 2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sulfuric acid; nitric acid; at -5 - 10 ℃; for 1h;
DOI:10.1021/jm060792t
Guidance literature:
Multi-step reaction with 3 steps
1: toluene; H2O / 21 h / 130 °C / Heating
2: 63.4 g / H2SO4 / 1.5 h / 80 - 90 °C
3: 93 percent / H2SO4; aq. HNO3 / 1 h / -5 - 10 °C
With sulfuric acid; nitric acid; In water; toluene;
DOI:10.1021/jm060792t
Guidance literature:
Multi-step reaction with 2 steps
1: 63.4 g / H2SO4 / 1.5 h / 80 - 90 °C
2: 93 percent / H2SO4; aq. HNO3 / 1 h / -5 - 10 °C
With sulfuric acid; nitric acid;
DOI:10.1021/jm060792t
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