836-31-7

Usage

Uses

Used in Pharmaceutical Industry:
4,4,4-Trifluoro-3-oxo-N-phenylbutanamide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its trifluoromethyl group and phenyl group contribute to the development of new drugs with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Agrochemical Industry:
In the agrochemical sector, 4,4,4-trifluoro-3-oxo-N-phenylbutanamide serves as a precursor in the production of agrochemicals, including pesticides and herbicides. Its structural features allow for the creation of compounds with targeted biological activity against pests and weeds, contributing to more effective and environmentally friendly agricultural practices.
Used in Medicinal Chemistry Research:
4,4,4-Trifluoro-3-oxo-N-phenylbutanamide is utilized in medicinal chemistry research for the design and optimization of bioactive molecules. Its unique structural elements, such as the trifluoromethyl group and the butanamide moiety, enable the exploration of novel chemical space and the development of compounds with potential therapeutic applications.
It is crucial to handle 4,4,4-trifluoro-3-oxo-N-phenylbutanamide with care due to its potential health and environmental hazards if not properly managed. Safe laboratory practices and appropriate disposal methods should be employed to minimize risks associated with this chemical compound.

Upstream product

• 62-53-3 aniline 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 25199-84-2 4-(trifluoromethyl)quinolin-2(1H)-one 
• 1590368-21-0 N-phenyl-1-[2-(phenylselanyl)phenyl]-5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxamide 
• 328956-38-3 6-nitro-4-trifluoromethylquinolin-2(1H)-one 
• 328955-57-3 6-amino-4-(trifluoromethyl)quinoline-2-(1H)-one 

Relevant academic research and scientific papers

Design, synthesis and insecticidal activities of dihydropyridine-fused neonicotinoids compounds with trifluoromethyl group

A series of novel neonicotinoids containing a dihydro-pyridine ring and a trifluoromethyl group were designed and synthesized by multicomponent reactions of 6-Cl-PMNI, triethoxymethane and 4,4,4-trifluoro-3-oxobutaneanilides (9) under solvent-free and cat

Discovery of 6-N,N-Bis(2,2,2-trifluoroethyl)amino-4- trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator

The androgen receptor is a member of the extended family of nuclear receptors and is widely distributed throughout the body. Androgen therapy is used to compensate for low levels of the natural hormones testosterone (T) and dihydrotestosterone and consist

An Improved Access to 4-Trifluoromethyl-2(1H)-quinolinones: The "Watering Protocol"

Condensation of anilines with ethyl 4,4,4-trifluoroacetoacetate (7) to afford the corresponding 4,4,4-trifluoro-3-oxobutaneanilides (10), precursors to 4-(trifluoromethyl)-2-quinolinones (11), can be favored and the competing condensation to produce the e

Chemoselectivity in the reactions between ethyl 4,4,4-trifluoro-3-oxobutanoate and anilines: Improved synthesis of 2-trifluoromethyl-4- and 4-trifluoromethyl-2-quinolinones

Chemoselectivity in the reactions between ethyl 4,4, 4-trifluoroacetoacetate (ethyl 4,4,4-trifluoro-3-oxobutanoate) and various anilines was systematically studied as a function of the reaction conditions used (solvent/temperature, catalyst). The results obtained allowed chemoselective (>90%) synthesis of the corresponding ethyl 3-arylamino-4,4,4-trifluorobut-2-enoates and N-aryl-4,4,4-trifluoro-3-oxobutyramides, which were cyclized to afford 2-trifluoromethyl-4-quinolinones and 4-trifluoromethyl-2-quinolinones, respectively.