6-Chloro-3-trifluoromethylpyridin-4-ylamine

Base Information

• Chemical Name: 6-Chloro-3-trifluoromethylpyridin-4-ylamine
• CAS No.: 1061358-78-8
• Molecular Formula: C6H4ClF3N2
• Molecular Weight: 196.56
• Mol file: 1061358-78-8.mol

Synonyms:2-CHLORO-5-TRIFLUOROMETHYL-PYRIDIN-4-YLAMINE;

Chemical Property of 6-Chloro-3-trifluoromethylpyridin-4-ylamine

Chemical Property:

• Boiling Point: 287.3±35.0 °C(Predicted)
• PKA: 2.48±0.42(Predicted)
• PSA: 38.91000
• Density: 1.507±0.06 g/cm3(Predicted)
• LogP: 2.91720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-5-(trifluoromethyl)pyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-chloro-5-(trifluoromethyl)pyridin-4-amine is a useful research chemical for organic synthesis and other chemical processes.

Technology Process of 6-Chloro-3-trifluoromethylpyridin-4-ylamine

There total 4 articles about 6-Chloro-3-trifluoromethylpyridin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl (2-chloro-5-(trifluoromethyl)pyridin-4-yl)carbamate → 2-chloro-5-(trifluoromethyl)pyridin-4-amine (1061358-78-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01938

Reference yield:

2-chloro-4-iodo-5-(trifluoromethyl)pyridine (505084-55-9) → 2-chloro-5-(trifluoromethyl)pyridin-4-amine (1061358-78-8) + 4-iodo-5-(trifluoromethyl)pyridin-2-amine

Guidance literature:

With ammonia; In methanol; at 130 ℃; for 1h; Microwave irradiation;

Reference yield:

2-chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid (505084-58-2) → 2-chloro-5-(trifluoromethyl)pyridin-4-amine (1061358-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 105 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1021/acs.jmedchem.5b01938

upstream raw materials:

2-chloro-4-iodo-5-(trifluoromethyl)pyridine

2-chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid

2-chloro-5-trifluoromethylpyridine

Downstream raw materials:

CCT245737

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