505084-55-9

Basic information

• Product Name: 2-chloro-5-(trifluoromethyl)-4-iodopyridine
• Synonyms: 2-chloro-5-(trifluoromethyl)-4-iodopyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine;2-Chloro-4-iodo-5-(trifluoroMethyl)pyridine, tech. 90%;6-Chloro-4-iodo-alpha,alpha,alpha-trifluoro-3-picoline;2-chloro -4-iodine -5- threefluorineMethyl pyridine;Pyridine, 2-chloro-4-iodo-5-(trifluoromethyl)-;505084-55-9
• CAS NO: 505084-55-9
• Molecular Formula: C₆H₂ClF₃IN
• Molecular Weight: 307.4394596
• EINECS: -0
• Product Categories: Halides;Pyridines
• Mol File: 505084-55-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 126.0 to 130.0 °C
• Boiling Point: 257.596 °C at 760 mmHg
• Flash Point: 109.59 °C
• Appearance: /Solid
• Density: 2.047 g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol
• PKA: -2.74±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-chloro-5-(trifluoromethyl)-4-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(trifluoromethyl)-4-iodopyridine(505084-55-9)
• EPA Substance Registry System: 2-chloro-5-(trifluoromethyl)-4-iodopyridine(505084-55-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 505084-55-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 505084-55-9 differently. You can refer to the following data:
1. 2-chloro-5-(trifluoromethyl)-4-iodopyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.
2. 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.

InChI:InChI=1/C6H2ClF3IN/c7-5-4(11)1-3(2-12-5)6(8,9)10/h1-2H

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 

Downstream Products

• 505084-56-0 2-chloro-3-iodo-5-(trifluoromethyl)pyridine 
• 1061358-78-8 2-chloro-5-(trifluoromethyl)pyridin-4-amine 
• 1061358-73-3 2-chloro-N-(3-(methylsulfonyl)benzyl)-5-(trifluoromethyl)pyridin-4-amine 
• 1061358-53-9 2-chloro-N-(2-(pyrimidin-2-yl)phenyl)-5-(trifluoromethyl)pyridin-4-amine 
• 1061358-64-2 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide 
• 505084-59-3 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid 
• 131747-40-5 5-(trifluoromethyl)pyridine-3-carboxylic acid 
• 796090-24-9 6-chloro-3-(trifluoromethyl)pyridine-2-carboxylic acid 
• 505084-57-1 2-chloro-5-(trifluoromethyl)pyridine-4-carbaldehyde 
• 505084-58-2 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid 

Relevant articles and documents

Polycyclic amide derivative as CDK9 inhibitor, and preparation method and application thereof

The invention belongs to the technical field of polycyclic amide derivatives, and particularly relates to a polycyclic amide derivative as a CDK9 inhibitor, and a preparation method and application thereof. The polycyclic amide derivative shows excellent CDK9 enzyme inhibitory activity, and can be used for preparing drugs for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors, such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia and follicular lymphoma, including breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

KINASE INHIBITORS

-

Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids

As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).