1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile

Base Information

• Chemical Name: 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile
• CAS No.: 1033772-22-3
• Molecular Formula: C7H4N4
• Molecular Weight: 144.13346
• Hs Code.: 2933990090
• Mol file: 1033772-22-3.mol

Synonyms:1H-pyrazolo[4,3-b]pyridine-5-carbonitrile

Chemical Property of 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile

Chemical Property:

• PSA: 65.36000
• LogP: 0.82958
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile

There total 1 articles about 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

trimethylsilyl cyanide (7677-24-9) + 4-hydroxy-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazolo[4,3-b]pyridinium (1033772-21-2) → 1H-pyrazolo[4,3-b]pyridine-5-carbonitrile (1033772-22-3)

Guidance literature:

trimethylsilyl cyanide; 4-hydroxy-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazolo[4,3-b]pyridinium; In dichloromethane; at 20 ℃; for 0.0833333h;

With N,N-Dimethylcarbamoyl chloride; In dichloromethane; at 20 ℃; for 96h;

Reference yield:

1H-pyrazolo[4,3-b]pyridine-5-carbonitrile (1033772-22-3) → 1H-pyrazolo[4,3-b]pyridine-5-carboxylic acid (1260670-03-8)

Guidance literature:

With hydrogenchloride; water; In methanol; for 6h; Heating / reflux;

upstream raw materials:

trimethylsilyl cyanide

4-hydroxy-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazolo[4,3-b]pyridinium

Downstream raw materials:

1H-pyrazolo[4,3-b]pyridine-5-carboxylic acid

Refernces