5-Chloro-3-fluoro-2-iodopyridine

Base Information

Chemical Name:5-Chloro-3-fluoro-2-iodopyridine
CAS No.:514797-98-9
Molecular Formula:C5H2ClFIN
Molecular Weight:257.43
Hs Code.:2933399990
DSSTox Substance ID:DTXSID80446922
Nikkaji Number:J1.861.133C
Wikidata:Q72450857
Mol file:514797-98-9.mol

Synonyms:5-Chloro-3-fluoro-2-iodopyridine;514797-98-9;5-hloro-3-luoro-2-odopyridine;SCHEMBL2194759;DTXSID80446922;2-Iodo-5-chloro-3-fluoropyridine;MFCD18256751;BS-50229;CS-0173258

Suppliers and Price of 5-Chloro-3-fluoro-2-iodopyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynChem
5-CHLORO-3-FLUORO-2-IODOPYRIDINE 95%
1 g
$ 750.00

Crysdot
5-Chloro-3-fluoro-2-iodopyridine 95+%
1g
$ 589.00

Chemenu
5-chloro-3-fluoro-2-iodopyridine 95%
1g
$ 557.00

American Custom Chemicals Corporation
5-CHLORO-3-FLUORO-2-IODOPYRIDINE 95.00%
5MG
$ 498.81

Alichem
5-Chloro-3-fluoro-2-iodopyridine
1g
$ 2837.10

Alichem
5-Chloro-3-fluoro-2-iodopyridine
250mg
$ 1009.40

Activate Scientific
5-Chloro-3-fluoro-2-iodopyridine 95%
1 g
$ 730.00

Aaron Chemicals
5-chloro-3-fluoro-2-iodopyridine 95%
250mg
$ 226.00

Aaron Chemicals
5-chloro-3-fluoro-2-iodopyridine 95%
100mg
$ 153.00

Total 10 raw suppliers

Chemical Property of 5-Chloro-3-fluoro-2-iodopyridine

Chemical Property:

Boiling Point:219.7±35.0 °C(Predicted)
PKA:-2.86±0.20(Predicted)
PSA：12.89000
Density:2.129±0.06 g/cm3(Predicted)
LogP:2.47870
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:256.89045
Heavy Atom Count:9
Complexity:103

Purity/Quality:

99%+ ^*data from raw suppliers

5-CHLORO-3-FLUORO-2-IODOPYRIDINE 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC(=C1F)I)Cl

Technology Process of 5-Chloro-3-fluoro-2-iodopyridine

There total 5 articles about 5-Chloro-3-fluoro-2-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 514797-97-8
2-bromo-5-chloro-3-fluoro-pyridine

: 514797-98-9
5-chloro-3-fluoro-2-iodopyridine

Guidance literature:: 2-bromo-5-chloro-3-fluoro-pyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 2h;

With iodine; In tetrahydrofuran; at -75 ℃; for 1h;
DOI:10.1002/1099-0690(200212)2002:24<4174::AID-EJOC4174>3.0.CO;2-6

Reference yield: 23.0%

: 514798-06-2
5-chloro-3-fluoro-2,4-diiodopyridine

: 514797-98-9
5-chloro-3-fluoro-2-iodopyridine

: 514798-10-8
3-chloro-5-fluoro-2,6-diiodopyridine

Guidance literature:: 5-chloro-3-fluoro-2,4-diiodopyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -75 ℃; for 0.25h;

With methanol;
DOI:10.1002/1099-0690(200212)2002:24<4174::AID-EJOC4174>3.0.CO;2-6

Reference yield:

: 89402-43-7
5-chloro-2,3-difluoropyridine

: 514797-98-9
5-chloro-3-fluoro-2-iodopyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / aq. sodium hydroxide / 20 h / 75 °C

2.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 °C

3.2: 59 percent / iodine / tetrahydrofuran / 1 h / -75 °C

With sodium hydroxide; isopropylmagnesium chloride; phosphorus(V) oxybromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/1099-0690(200212)2002:24<4174::AID-EJOC4174>3.0.CO;2-6