Synonyms:Wang resin
97% *data from raw suppliers
4-Benzyloxybenzyl alcohol resin *data from reagent suppliers
The research focuses on the synthesis and characterization of two novel β-peptides, a β-octapeptide (2) and a β-decapeptide (3), containing β3-homohistidine and β3-homocysteine building blocks. These peptides were designed to form hairpin and 314-helical secondary structures, respectively, and their ability to bind Zn2+ ions in aqueous solution was investigated. The peptides were synthesized using solid-phase synthesis and characterized by high-resolution mass spectrometry. Wang resin was used as the solid support for manual solid-phase peptide synthesis. Circular-dichroism (CD) measurements were employed to analyze the secondary structure of the peptides in both methanol and water, with and without the addition of Zn2+ ions. The study observed changes in the CD spectra upon Zn2+ binding, indicating alterations in the peptides' secondary structures. The experiments aimed to understand the stabilization of peptide secondary structures through metal-ion complexation, which has implications for the design of peptidomimetic compounds.
The research focuses on the synthesis and application of a new soluble polymer analogue of Wang resin in solid-phase chemistry, specifically for inter-molecular radical additions of xanthates onto olefins. The experiments compared the new resin with a classical Wang resin, examining the efficiency of radical transfer and cleavage conditions. Reactants included xanthates, olefins, and the new soluble polymer, with reactions monitored using 'H NMR spectroscopy for easy tracking of the reaction progress. The analyses involved various techniques such as 'H and "C NMR, infrared spectroscopy, mass spectrometry, HPLC, and TLC to characterize the reactants, intermediates, and final products. The study demonstrated that the new soluble polymer provided better results for radical transfer, preserved the efficient cleavage conditions of the Wang linker, and allowed for easier monitoring of reactions compared to the classical Wang resin.
This research aimed to develop a solid-phase synthetic strategy for preparing fluorescent and/or lanthanide-labeled derivatives of the δ-opioid receptor (δOR) ligand H-Dmt-Tic-Lys(R)-OH, with the goal of creating high-contrast noninvasive molecular markers for live imaging ex vivo or in vivo. The study focused on the Cy5 derivative 1, which demonstrated high δ-OR affinity (Ki = 3 nM) and desirable in vivo characteristics, making it useful for structure-function studies, receptor localization, and as a molecular marker. Key chemicals used in the synthetic process included Fmoc-protected amino acids, Wang resin for solid-phase peptide synthesis, and labeling moieties such as Cy5 dye and the lanthanide chelator DOTA.
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