6-chloro-N4-cyclopropylpyrimidine-4,5-diamine

Base Information

• Chemical Name: 6-chloro-N4-cyclopropylpyrimidine-4,5-diamine
• CAS No.: 195252-62-1
• Molecular Formula: C7H9ClN4
• Molecular Weight: 184.628
• Mol file: 195252-62-1.mol

Synonyms:6-Chloro-N4-cyclopropyl-pyrimidine-4,5-diamine;6-CHLORO-N4-CYCLOPROPYLPYRIMIDINE-4,5-DIAMINE;6-chloro-N-cyclopropylpyrimidine-4,5-diamine;5-amino-6-chloro-4-cyclopropylaminopyrimidine;5-amino-4-chloro-6-(N-cyclopropylamino)pyrimidine;

Chemical Property of 6-chloro-N4-cyclopropylpyrimidine-4,5-diamine

Chemical Property:

• PSA: 63.83000
• LogP: 1.94070

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-N4-cyclopropylpyrimidine-4,5-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-N4-cyclopropylpyrimidine-4,5-diamine

There total 1 articles about 6-chloro-N4-cyclopropylpyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-amino-4,6-dichloropyridimine (5413-85-4) + Cyclopropylamine (765-30-0) → 5-amino-4-chloro-6-(N-cyclopropylamino)pyrimidine (195252-62-1)

Guidance literature:

In propan-1-ol; 1.) 3 h, reflux, 2.) RT, 3 d;

DOI:10.1021/jm960662s

Reference yield: 80.0%

orthoformic acid triethyl ester (122-51-0) + 5-amino-4-chloro-6-(N-cyclopropylamino)pyrimidine (195252-62-1) → 6-chloro-9-cyclopropyl-9H-purine (6627-30-1)

Guidance literature:

With ethanesulfonic acid; for 46h; Ambient temperature;

DOI:10.1021/jm960662s

Reference yield: 67.0%

3-methoxy-benzaldehyde (591-31-1) + 5-amino-4-chloro-6-(N-cyclopropylamino)pyrimidine (195252-62-1) → 9-cyclopropyl-8-(3-methoxy-phenyl)-9H-purine-6-thiol

Guidance literature:

With sulfur; In N,N-dimethyl-formamide; at 100 ℃; for 17h;

DOI:10.1016/j.tetlet.2004.01.105

upstream raw materials:

5-amino-4,6-dichloropyridimine

Cyclopropylamine

Downstream raw materials:

6-chloro-9-cyclopropyl-9H-purine

Cyclopropyl-(9-cyclopropyl-9H-purin-6-yl)-amine

6-(4-chlorophenyl)-N-cyclopropylpyrimidine-4,5-diamine