1-(2-fluorophenyl)-2-nitroethanol

Base Information

• Chemical Name: 1-(2-fluorophenyl)-2-nitroethanol
• CAS No.: 1251400-54-0
• Molecular Formula: C8H8FNO3
• Molecular Weight: 185.15
• Mol file: 1251400-54-0.mol

Synonyms:Benzenemethanol, 2-fluoro-α-(nitromethyl)-;

Chemical Property of 1-(2-fluorophenyl)-2-nitroethanol

Chemical Property:

• PSA: 66.05000
• LogP: 1.65900

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-fluorophenyl)-2-nitroethanol

There total 12 articles about 1-(2-fluorophenyl)-2-nitroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

nitromethane (75-52-5) + 2-Fluorobenzaldehyde (446-52-6) → C8H8FNO3 (1251400-54-0)

Guidance literature:

nitromethane; 2-Fluorobenzaldehyde; With N-ethyl-N,N-diisopropylamine; C₄₄H₅₄CoN₂O₂; In dichloromethane; at -78 ℃; for 18h;

With water; In tetrahydrofuran; dichloromethane; Product distribution / selectivity;

Reference yield: 99.0%

nitromethane (75-52-5) + 2-Fluorobenzaldehyde (446-52-6) → (S)-(+)-1-(3-fluorophenyl)-2-nitroethanol (1251400-54-0)

Guidance literature:

With 1-ethyl-piperidine; 3,5-bistrifluoromethylbenzoic acid; bis((3,5-bis(trifluoromethyl)phenyl)ureido)-(salen)cobalt; In dichloromethane; at -70 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.201107785

Reference yield: 99.0%

nitromethane (75-52-5) + 2-Fluorobenzaldehyde (446-52-6) → (S)-(+)-1-(3-fluorophenyl)-2-nitroethanol (1251400-54-0) + (R)-1-(2-fluorophenyl)-2-nitroethan-1-ol (1251400-54-0)

Guidance literature:

With C₆₂H₅₀CuN₂O₂; In ethanol; at 10 ℃; for 24h; enantioselective reaction;

DOI:10.1002/asia.201200388

upstream raw materials:

nitromethane

2-Fluorobenzaldehyde

2-nitropropane

Refernces

• 1、 Wu, Shengying,Tang, Jun,Han, Jianwei,Mao, Dan,Liu, Xin,Gao, Xing,Yu, Jianjun,Wang, Limin. "Design of C2-symmetric salen ligands and their Co(II)- or Yb(III)-complexes, and their role in the reversal of enantioselectivity in the asymmetric Henry reaction". . p. 5986 - 5992. Retrieved 2014.
• 2、 Kogami, Youichi,Nakajima, Takahiro,Ashizawa, Tomoko,Kezuka, Satoko,Ikeno, Taketo,Yamada, Tohru. "Enantioselective Henry reaction catalyzed by optically active ketoiminatocobalt complexes". . p. 614 - 615. Retrieved 2004.
• 3、 Kogami, Youichi,Nakajima, Takahiro,Ikeno, Taketo,Yamada, Tohru. "Enantioselective Henry reaction catalyzed by salen-cobalt complexes". . p. 1947 - 1950. Retrieved 2004.
• 4、 Li, Li-Hua,Feng, Xiao-Lin,Cui, Xiao-Hui,Ma, Yun-Xiang,Ding, San-Yuan,Wang, Wei. "Salen-Based Covalent Organic Framework". . p. 6042 - 6045. Retrieved 2017.
• 5、 Cai, Zedong,Lan, Ting,Ma, Pengfei,Zhang, Jingfang,Yang, Qingqing,He, Wei. "A new type of L-Tertiary leucine-derived ligand: Synthesis and application in Cu(II)-catalyzed asymmetric Henry reactions". supporting information. . Retrieved 2019/08/08.
• 6、 Dixit, Ashish,Kumar, Pramod,Yadav, Geeta Devi,Singh, Surendra. "Asymmetric Henry reaction catalyzed by chiral Cu(II) salalen and salan complexes derived from (S)-proline". . p. 240 - 246. Retrieved 2018/05/22.