10.1039/jr9620003040
The research investigates the interaction of acrylonitrile and benzaldehyde in the presence of various compounds, including methanol, piperidine, and 2-nitropropane. 2-nitropropane is used as one of the key reactants to study its interaction with acrylonitrile and benzaldehyde in the presence of Triton B. The purpose is to investigate the cyanoethylation process and the effect of benzaldehyde on the reaction mechanism. When 2-nitropropane is used in combination with benzaldehyde and acrylonitrile, it leads to the formation of specific products, including 2,2'-cyanoethyl-2-nitropropane and a high-boiling alcohol, which upon dehydration yields a-(2-methyl-2-nitropropyl)cinnamonitrile. These products provide evidence for the interference of benzaldehyde in the cyanoethylation process, similar to its role in reactions with methanol and piperidine. The study concludes that the extent of benzaldehyde's interference in these reactions can provide insights into the rate of protonation of intermediate carbanions.
10.1016/S0040-4020(01)87129-5
The study investigates the SRN1 reaction between 2-chloromethyl-3-nitroimidazo[1,2-a]pyridine and various nitronate anions, including those from aliphatic, cyclic, and heterocyclic nitroalkanes, to synthesize new potential pharmacological derivatives. The reaction involves the C-alkylation of 2-chloromethyl-3-nitroimidazo[1,2-a]pyridine by nitronate anions, followed by base-promoted nitrous acid elimination to form products with a trisubstituted double bond at the 2-position. Key chemicals include 2-chloromethyl-3-nitroimidazo[1,2-a]pyridine as the starting material, various nitroalkanes (e.g., 2-nitropropane, nitrocyclopentane) as sources of nitronate anions, and tetrabutylammonium hydroxide as a phase-transfer catalyst. The synthesized compounds are being evaluated for their potential pharmacological properties, particularly their affinity for specific receptors related to anxiolytic and hypnotic effects.
T:Toxic;
