6-[(3-Chloro-2-fluorophenyl)Methyl]-7-fluoro-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]

Base Information

Chemical Name:6-[(3-Chloro-2-fluorophenyl)Methyl]-7-fluoro-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]
CAS No.:869893-92-5
Molecular Formula:C22H20ClF2NO4
Molecular Weight:435.855
Hs Code.:
Mol file:869893-92-5.mol

Synonyms:7-Desmethoxy-7-fluoro Elvitegravir;

Suppliers and Price of 6-[(3-Chloro-2-fluorophenyl)Methyl]-7-fluoro-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Desmethoxy-7-fluoroElvitegravir
25mg
$ 1390.00

TRC
7-Desmethoxy-7-fluoroElvitegravir
2.5mg
$ 180.00

Medical Isotopes, Inc.
7-Desmethoxy-7-fluoroElvitegravir
25 mg
$ 2400.00

Total 5 raw suppliers

Chemical Property of 6-[(3-Chloro-2-fluorophenyl)Methyl]-7-fluoro-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]

Chemical Property:

Boiling Point:595.0±50.0 °C(Predicted)
PKA:6.32±0.41(Predicted)
PSA：79.53000
Density:1.405±0.06 g/cm3(Predicted)
LogP:4.41150
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

7-Desmethoxy-7-fluoroElvitegravir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Elvitegravir (E509000) derivative.

Technology Process of 6-[(3-Chloro-2-fluorophenyl)Methyl]-7-fluoro-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]

There total 21 articles about 6-[(3-Chloro-2-fluorophenyl)Methyl]-7-fluoro-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 697762-62-2
(S)-ethyl 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-(1-(methoxycarbonyloxy)-3-methylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 869893-92-5
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: (S)-ethyl 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-(1-(methoxycarbonyloxy)-3-methylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate; With sodium hydroxide; water; In isopropyl alcohol; at 20 ℃; for 3h;

With hydrogenchloride; In water; isopropyl alcohol;

Reference yield: 62.0%

: 697762-66-6
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-[1-(S)-tert-butyldimethylsilyloxymethyl-2-methylprop-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 869893-92-5
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-[1-(S)-tert-butyldimethylsilyloxymethyl-2-methylprop-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; With sodium hydroxide; water; isopropyl alcohol; for 2 - 2.5h; Heating / reflux;

With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 2h; Product distribution / selectivity;