Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate

Base Information

Chemical Name:Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate
CAS No.:697762-39-3
Molecular Formula:C14H14F2INO3
Molecular Weight:409.171
Hs Code.:
DSSTox Substance ID:DTXSID90699588

Synonyms:697762-39-3;Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate;DTXSID90699588

Suppliers and Price of Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:408.99865
Heavy Atom Count:21
Complexity:428

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=CN(C)C)C(=O)C1=CC(=C(C=C1F)F)I

Technology Process of Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate

There total 6 articles about Ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 412319-88-1
ethyl-3,3-dimethylaminoacrylate

: 161531-51-7
2,4-difluoro-5-iodobenzoic acid

: 697762-39-3
ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)acrylate

Guidance literature:: 2,4-difluoro-5-iodobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In ethyl acetate; at 20 ℃; for 2h;

ethyl-3,3-dimethylaminoacrylate; With triethylamine; In tetrahydrofuran; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield: 52.0%

: 697762-39-3
ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)acrylate

Guidance literature:: With triethylamine; In toluene; at 90 ℃; for 4h;

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 697762-39-3
ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)acrylate

Guidance literature:: 2,4-difluoro-5-iodobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 20 ℃; for 12h;

ethyl 3-(dimethylamino)acrylate; With triethylamine; In tetrahydrofuran; toluene; for 1h; Product distribution / selectivity; Heating / reflux;