1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid
• CAS No.: 1067239-08-0
• Molecular Formula: C10H17NO5
• Molecular Weight: 231.249
• Hs Code.: 2933990090
• Mol file: 1067239-08-0.mol

Synonyms:1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid;1-Boc-3-hydroxypyrrolidine-3-carboxylic acid;3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid

Chemical Property of 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid

Chemical Property:

• Boiling Point: 384.6±42.0 °C(Predicted)
• PKA: 3.74±0.20(Predicted)
• PSA: 87.07000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 0.38080
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid

There total 3 articles about 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

C13H23NO5 → 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid (1067239-08-0)

Guidance literature:

With water; barium(II) hydroxide; In methanol; for 12h; Reflux;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-hydroxypyrrolidine-3-carboxylic acid (75315-60-5) → 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid (1067239-08-0)

Guidance literature:

di-tert-butyl dicarbonate; 3-hydroxypyrrolidine-3-carboxylic acid; With water; sodium hydroxide; In isopropyl alcohol; at 0 - 20 ℃; for 4h;

With phosphoric acid; In water; pH=3;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + di-tert-butyl dicarbonate (24424-99-5) + 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) → 1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-3-carboxylic acid (1067239-08-0)

Guidance literature:

trimethylsilyl cyanide; 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; With zinc(II) iodide; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In water; acetic acid; for 2 - 3h; Reflux;

di-tert-butyl dicarbonate; With sodium hydroxide; In water; isopropyl alcohol; at 0 - 20 ℃; for 4h;

upstream raw materials:

di-tert-butyl dicarbonate

3-hydroxypyrrolidine-3-carboxylic acid

trimethylsilyl cyanide

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

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