(3R,4S)-1-TERT-BUTYL 3-ETHYL 4-AMINOPYRROLIDINE-1,3-DICARBOXYLATE

Base Information

• Chemical Name: (3R,4S)-1-TERT-BUTYL 3-ETHYL 4-AMINOPYRROLIDINE-1,3-DICARBOXYLATE
• CAS No.: 895243-98-8
• Molecular Formula: C12H22N2O4
• Molecular Weight: 258.31
• Hs Code.: 2933399990
• Mol file: 895243-98-8.mol

Synonyms:(3R,4S)-1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate;(3R,4S)-1-tert-Butyl3-ethyl4-aminopyrrolidine-1,3-dicarboxylate;

Chemical Property of (3R,4S)-1-TERT-BUTYL 3-ETHYL 4-AMINOPYRROLIDINE-1,3-DICARBOXYLATE

Chemical Property:

• Boiling Point: 336.5±42.0 °C(Predicted)
• PKA: 8.85±0.40(Predicted)
• PSA: 81.86000
• Density: 1.129±0.06 g/cm3(Predicted)
• LogP: 1.38190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(3R,4S)-Ethyl1-Boc-4-aminopyrrolidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R,4S)-1-TERT-BUTYL 3-ETHYL 4-AMINOPYRROLIDINE-1,3-DICARBOXYLATE

There total 3 articles about (3R,4S)-1-TERT-BUTYL 3-ETHYL 4-AMINOPYRROLIDINE-1,3-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]-4-ethoxycarbonylpyrrolidine (267230-40-0) → (3R,4S)-4-Amino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (895243-98-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 16h;

Reference yield:

(3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]pyrrolidine-4-carboxylic acid ethyl ester hydrochloride (346610-81-9,267230-41-1) → (3R,4S)-4-Amino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (895243-98-8)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja010734r

Reference yield:

4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (146256-98-6) → (3R,4S)-4-Amino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (895243-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 4 h

1.2: 16 h / 75 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; ethanol;

upstream raw materials:

(3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]-4-ethoxycarbonylpyrrolidine

(3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]pyrrolidine-4-carboxylic acid ethyl ester hydrochloride

4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Downstream raw materials:

(3R,4S)-4-Allyloxycarbonylamino-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-3-carboxylic acid ethyl ester