Technology Process of 5-chloro-8-iodoquinoline
There total 8 articles about 5-chloro-8-iodoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-chloroquinolin-8-amine;
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 ℃;
for 0.5h;
Inert atmosphere;
With
potassium iodide;
In
water;
at 0 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1055/s-0036-1588420
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium chloride; dipotassium peroxodisulfate / acetonitrile / 1.5 h / 80 °C / Inert atmosphere
2.1: sodium hydroxide; ethanol / 12 h / Reflux; Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere
3.2: 2.5 h / 0 °C / Inert atmosphere
With
hydrogenchloride; dipotassium peroxodisulfate; ethanol; lithium chloride; sodium hydroxide; sodium nitrite;
In
water; acetonitrile;
DOI:10.1055/s-0036-1588420
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide; ethanol / 12 h / Reflux; Inert atmosphere
2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere
2.2: 2.5 h / 0 °C / Inert atmosphere
With
hydrogenchloride; ethanol; sodium hydroxide; sodium nitrite;
In
water;
DOI:10.1055/s-0036-1588420
